Update of the statements on biology and clinical impact of occult hepatitis B virus infection

Giovanni Raimondo¹, Stephen Locarnini², Teresa Pollicino³, Massimo Levrero⁴, Fabien Zoulim⁴, Anna S Lok⁵; Taormina Workshop on Occult HBV Infection Faculty Members

Collaborators, Affiliations

Collaborators

Taormina Workshop on Occult HBV Infection Faculty Members:
Jean-Pierre Allain⁶, Thomas Berg⁷, Antonio Bertoletti⁸, Maurizia Rossana Brunetto⁹, Raffaele Bruno¹⁰, Ding-Shinn Chen¹¹, Nicola Coppola¹², Markus Cornberg¹³, Antonio Craxì¹⁴, Maura Dandri¹⁵, Vito Di Marco¹⁶, Carlo Ferrari¹⁷, Giovanni Battista Gaeta¹⁸, Dieter Glebe¹⁹, Luca G Guidotti²⁰, Anna Kramvis²¹, Pietro Lampertico²², Chengyao Li²³, Jake Liang²⁴, Alfredo Marzano²⁵, Thomas I Michalak²⁶, Jean-Michel Pawlotsky²⁷, Daniele Prati²⁸, Massimo Puoti²⁹, Didier Samuel³⁰, Vincent Soriano³¹, Giovanni Squadrito³², Camille Sureau³³, Christian Trepo³⁴, Man-Fung Yuen³⁵

Affiliations

¹ Division of Clinical and Molecular Hepatology, University of Messina, Messina, Italy; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. Electronic address: raimondo@unime.it.
² Victorian Infectious Diseases Reference Laboratory at the Doherty Institute, Melbourne, Victoria, Australia.
³ Division of Clinical and Molecular Hepatology, University of Messina, Messina, Italy; Department of Human Pathology, University of Messina, Messina, Italy.
⁴ Cancer Research Center of Lyon, INSERM U1052, Hospices Civils de Lyon, Lyon University, Lyon, France.
⁵ Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
⁶ Department of Haematology, University of Cambridge, United Kingdom.
⁷ Department of Hepatology, University Hospital, Leipzig, Germany.
⁸ Singapore Institutes for Clinical Sciences, Singapore.
⁹ Internal Medicine, Department of Clinical and Experimental Medicine, Pisa University and Liver Unit, University Hospital of Pisa, Italy.
¹⁰ Division of Infectious Diseases, University of Pavia, Italy.
¹¹ Department of Internal Medicine, National Taiwan University College of Medicine, Taiwan.
¹² Infectious Disease Unit, University of Campania, Italy.
¹³ Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
¹⁴ Division of Gastroenterology and Hepatology, University Hospital of Palermo, Italy.
¹⁵ Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹⁶ University Hospital of Palermo, Italy.
¹⁷ Department of Medicine and Surgery, University of Parma, Italy.
¹⁸ Division of Infectious Diseases, University of Campania, Naples, Italy.
¹⁹ Justus-Liebig University of Giessen, Institute of Medical Virology, National Reference Centre for Hepatitis B and D Viruses, Biomedical Research Centre Seltersberg, Giessen, Germany.
²⁰ IRCCS San Raffaele Scientific Institute, Milan, Italy.
²¹ Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa.
²² Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
²³ Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
²⁴ NIDDK-NIH, USA.
²⁵ Division of Gastroenterology, University Hospital of Torino, Italy.
²⁶ Faculty of Medicine, Memorial University, St. John's, NL, Canada.
²⁷ Department of Virology & INSERM U955, Henri Mondor Hospital, University of Paris-Est, Créteil, France.
²⁸ Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
²⁹ Division of Infectious Diseases, Niguarda Hospital, Milan, Italy.
³⁰ Centre HépatoBiliaire, University Hôpital Paul Brousse, France.
³¹ UNIR Health Science School & Infectious Diseases & Tropical Medicine, La Paz University Madrid, Spain.
³² Division of Clinical and Molecular Hepatology, Department of Clinical and Experimental Medicine, University of Messina, Italy.
³³ Transfusion Institut National de la Transfusion Sanguine INSERM U134, Paris, France.
³⁴ Internal Medicine Department, Hospices Civils de Lyon, Lyon, France.
³⁵ Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

PMID: 31004683
DOI: 10.1016/j.jhep.2019.03.034

Free article

Review

Update of the statements on biology and clinical impact of occult hepatitis B virus infection

Giovanni Raimondo et al. J Hepatol. 2019 Aug.

Free article

. 2019 Aug;71(2):397-408.

doi: 10.1016/j.jhep.2019.03.034. Epub 2019 Apr 18.

Authors

Giovanni Raimondo¹, Stephen Locarnini², Teresa Pollicino³, Massimo Levrero⁴, Fabien Zoulim⁴, Anna S Lok⁵; Taormina Workshop on Occult HBV Infection Faculty Members

Collaborators

Taormina Workshop on Occult HBV Infection Faculty Members:
Jean-Pierre Allain⁶, Thomas Berg⁷, Antonio Bertoletti⁸, Maurizia Rossana Brunetto⁹, Raffaele Bruno¹⁰, Ding-Shinn Chen¹¹, Nicola Coppola¹², Markus Cornberg¹³, Antonio Craxì¹⁴, Maura Dandri¹⁵, Vito Di Marco¹⁶, Carlo Ferrari¹⁷, Giovanni Battista Gaeta¹⁸, Dieter Glebe¹⁹, Luca G Guidotti²⁰, Anna Kramvis²¹, Pietro Lampertico²², Chengyao Li²³, Jake Liang²⁴, Alfredo Marzano²⁵, Thomas I Michalak²⁶, Jean-Michel Pawlotsky²⁷, Daniele Prati²⁸, Massimo Puoti²⁹, Didier Samuel³⁰, Vincent Soriano³¹, Giovanni Squadrito³², Camille Sureau³³, Christian Trepo³⁴, Man-Fung Yuen³⁵

Affiliations

¹ Division of Clinical and Molecular Hepatology, University of Messina, Messina, Italy; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. Electronic address: raimondo@unime.it.
² Victorian Infectious Diseases Reference Laboratory at the Doherty Institute, Melbourne, Victoria, Australia.
³ Division of Clinical and Molecular Hepatology, University of Messina, Messina, Italy; Department of Human Pathology, University of Messina, Messina, Italy.
⁴ Cancer Research Center of Lyon, INSERM U1052, Hospices Civils de Lyon, Lyon University, Lyon, France.
⁵ Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
⁶ Department of Haematology, University of Cambridge, United Kingdom.
⁷ Department of Hepatology, University Hospital, Leipzig, Germany.
⁸ Singapore Institutes for Clinical Sciences, Singapore.
⁹ Internal Medicine, Department of Clinical and Experimental Medicine, Pisa University and Liver Unit, University Hospital of Pisa, Italy.
¹⁰ Division of Infectious Diseases, University of Pavia, Italy.
¹¹ Department of Internal Medicine, National Taiwan University College of Medicine, Taiwan.
¹² Infectious Disease Unit, University of Campania, Italy.
¹³ Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
¹⁴ Division of Gastroenterology and Hepatology, University Hospital of Palermo, Italy.
¹⁵ Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹⁶ University Hospital of Palermo, Italy.
¹⁷ Department of Medicine and Surgery, University of Parma, Italy.
¹⁸ Division of Infectious Diseases, University of Campania, Naples, Italy.
¹⁹ Justus-Liebig University of Giessen, Institute of Medical Virology, National Reference Centre for Hepatitis B and D Viruses, Biomedical Research Centre Seltersberg, Giessen, Germany.
²⁰ IRCCS San Raffaele Scientific Institute, Milan, Italy.
²¹ Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa.
²² Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.
²³ Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
²⁴ NIDDK-NIH, USA.
²⁵ Division of Gastroenterology, University Hospital of Torino, Italy.
²⁶ Faculty of Medicine, Memorial University, St. John's, NL, Canada.
²⁷ Department of Virology & INSERM U955, Henri Mondor Hospital, University of Paris-Est, Créteil, France.
²⁸ Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
²⁹ Division of Infectious Diseases, Niguarda Hospital, Milan, Italy.
³⁰ Centre HépatoBiliaire, University Hôpital Paul Brousse, France.
³¹ UNIR Health Science School & Infectious Diseases & Tropical Medicine, La Paz University Madrid, Spain.
³² Division of Clinical and Molecular Hepatology, Department of Clinical and Experimental Medicine, University of Messina, Italy.
³³ Transfusion Institut National de la Transfusion Sanguine INSERM U134, Paris, France.
³⁴ Internal Medicine Department, Hospices Civils de Lyon, Lyon, France.
³⁵ Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

PMID: 31004683
DOI: 10.1016/j.jhep.2019.03.034

Abstract

In October 2018 a large number of international experts with complementary expertise came together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI). The objectives of the workshop were to review the existing knowledge on OBI, to identify issues that require further investigation, to highlight both existing controversies and newly emerging perspectives, and ultimately to update the statements previously agreed in 2008. This paper represents the output from the workshop.

Keywords: HBV S variants; HBV cccDNA; HBV reactivation; HBV transmission; Hepatocellular carcinoma; OBI; Occult HBV infection.

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Update of the statements on biology and clinical impact of occult hepatitis B virus infection

Collaborators

Affiliations

Update of the statements on biology and clinical impact of occult hepatitis B virus infection

Authors

Collaborators

Affiliations

Abstract

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical