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. 2019 Nov;42(11):1361-1363.
doi: 10.1007/s40618-019-01051-4. Epub 2019 Apr 20.

Impact of CFTR-modulating drugs on GH-IGF-1 axis impairment in adult patients with cystic fibrosis

C Pascucci  1 , R V De Biase  2 , D Savi  2   3 , S Quattrucci  4 , L Gnessi  5 , C Lubrano  5 , A Lenzi  5
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Impact of CFTR-modulating drugs on GH-IGF-1 axis impairment in adult patients with cystic fibrosis

C Pascucci et al. J Endocrinol Invest. 2019 Nov.

Abstract

Introduction: A new class of drugs in the treatment of cystic fibrosis (CF) includes two agents: lumacaftor, which corrects CFTR channel protein, and ivacaftor, which increases CFTR channel activity. In our previous study we recruited 50 stable adults with CF and 16 of them showed growth hormone deficit (GHD): 7 patients severe and 9 patients partial GHD.

Material and methods: We decided to re-evaluate ten patients with the GHRH + arginine test of whom only five were treated with lumacaftor/ivacaftor.

Results: All CF patients in therapy with lumacaftor/ivacaftor showed a marked improvement in GHD. Two patients moved from a severe GHD to a normal response to the GH/IGF-1 axis test, and three patients who had partial GHD moved to normal response.

Conclusion: The pituitary gland may be damaged by CF disease and could benefit of the action of correcting drugs.

Keywords: Adult patients; Cystic fibrosis; Growth hormone; Insulin-like growth factor-1; Ivacaftor; Lumacaftor.

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