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. 2019 May;597(10):2599-2601.
doi: 10.1113/JP277501. Epub 2019 Apr 21.

CrossTalk opposing view: Heart rate variability as a measure of cardiac autonomic responsiveness is fundamentally flawed

Mark Boyett  1 , Yanwen Wang  1 , Alicia D'Souza  1
Affiliations

CrossTalk opposing view: Heart rate variability as a measure of cardiac autonomic responsiveness is fundamentally flawed

Mark Boyett et al. J Physiol. 2019 May.
No abstract available

Keywords: Autonomic nervous system; Heart rate; Heart rate variability.

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Figures

Figure 1
Figure 1. Heart rate dependence of HRV
A, relationship between HRV (SDNN) and heart rate from a wide range of studies. It includes data from the healthy conscious human, athletically trained conscious human, conscious human exposed to autonomic blockade, conscious human with heart failure, conscious human with hypertrophic cardiomyopathy, conscious human with myocardial infarction, conscious human heart transplant recipient, conscious mouse (wild type and transgenic), rat, Langendorff‐perfused rabbit and rat hearts, and rabbit sinus node cells (control and exposed to acetylcholine). The black line is the relationship between SDNN and heart rate predicted by the mathematical model of Monfredi et al. (2014). From Monfredi et al. (2014). B, change in HRV (total power) during high intensity exercise (cycloergometer) in an elite cyclist. Data are shown for a single individual, but similar changes were observed in 10 other elite cyclists. From Sarmiento et al. (2013). C, relationship between high frequency power (PSD) and heart rate during high intensity exercise in an elite cyclist. Data are shown for one representative subject. From Sarmiento et al. (2013). D, mean SDNN ± SD plotted as a function of mean heart rate ± SD for a group of 10 patients with inappropriate sinus tachycardia and 10 control age‐ and sex‐matched control subjects. From Castellanos et al. (1998). The red line is the relationship between SDNN and heart rate predicted by the mathematical model of Monfredi et al. (2014). E, fitted regression lines of 2 h SDNN as a function of age for 2722 male and female human subjects. Data are shown for five specific ages (35, 45, 55, 65 and 75 years) at mean heart rates between 50 and 100 beats/min. From Tsuji et al. (1996). PSD, power spectral density.
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References

    1. Achike O & DeAntonio H (2018). Ivabradine and inappropriate sinus tachycardia: a funny target for an inappropriate disease. J Am Coll Cardiol 71 (suppl.), 2606.
    1. Casadei B, Cochrane S, Johnston J, Conway J & Sleight P (1995). Pitfalls in the interpretation of spectral analysis of the heart rate variability during exercise in humans. Acta Physiol Scand 153, 125–131. - PubMed
    1. Castellanos A, Moleiro F, Chakko S, Acosta H, Huikuri H, Mitrani RD & Myerburg RJ (1998). Heart rate variability in inappropriate sinus tachycardia. Am J Cardiol 82, 531–534. - PubMed
    1. D'Souza A, Bucchi A, Johnsen AB, Logantha SJRJ, Monfredi O, Yanni J, Prehar S, Hart G, Cartwright E, Wisloff U, Dobryznski H, DiFrancesco D, Morris GM & Boyett MR (2014). Exercise training reduces resting heart rate via downregulation of the funny channel HCN4. Nat Commun 5, 3775. - PMC - PubMed
    1. D'Souza A, Pearman CM, Wang Y, Nakao S, Logantha SJRJ, Cox C, Bennett H, Zhang Y, Johnsen AB, Linscheid N, Poulsen PC, Elliott J, Coulson J, McPhee J, Robertson A, Da Costa Martins PA, Kitmitto A, Wisløff U, Cartwright EJ, Monfredi O, Lundby A, Dobrzynski H, Oceandy D, Morris GM & Boyett MR (2017). Targeting miR‐423‐5p reverses exercise training‐induced HCN4 channel remodeling and sinus bradycardia. Circ Res 121, 1058–1068. - PMC - PubMed

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