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Randomized Controlled Trial
. 2020 Feb;24(1):34-41.
doi: 10.1111/1744-9987.12813. Epub 2019 Jun 17.

Lidocaine-Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated With Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis: A Placebo-Controlled, Double-Blind, Crossover Study

Seishi Aihara  1   2 , Shunsuke Yamada  2 , Satoru Shichijo  1 , Kento Fukumitsu  1 , Mika Kondo  1 , Yutaro Hirashima  1 , Hideaki Oka  1 , Taro Kamimura  1 , Atsumi Harada  1 , Toshiaki Nakano  2 , Kazuhiko Tsuruya  3 , Takanari Kitazono  2
Affiliations
Randomized Controlled Trial

Lidocaine-Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated With Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis: A Placebo-Controlled, Double-Blind, Crossover Study

Seishi Aihara et al. Ther Apher Dial. 2020 Feb.

Abstract

Vascular access intervention therapy (VAIVT) is necessary to maintain vascular access in patients undergoing hemodialysis. VAIVT-associated vasodilatation is painful. However, few reports have focused on effective pain relief at the time of VAIVT. The present study was performed to determine whether lidocaine-propitocain cream, a eutectic mixture of local anesthetics (EMLA), effectively reduces VAIVT-associated pain in patients undergoing hemodialysis. This placebo-controlled, double-blind, crossover study was conducted in a single center. Among 210 patients who underwent a total of 437 VAIVT procedures from August 2017 to June 2018, 30 patients were randomly allocated to either the EMLA-placebo arm or placebo-EMLA arm at the time of VAIVT. EMLA application significantly reduced the visual analog scale score compared with placebo (47.0 ± 21.1 vs. 68.6 ± 20.7 mm, respectively; P < 0.05). EMLA is a safe and effective treatment for relief of VAIVT-associated pain in patients undergoing hemodialysis.

Keywords: Eutectic mixtures of local anesthetics; Hemodialysis; Pain relief; Vascular access intervention therapy.

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References

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