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Review
. 2019 Jan-Mar;12(1):4-18.
doi: 10.4103/jhrs.JHRS_150_18.

Role of Oxidative Stress in Male Infertility: An Updated Review

Ahmed T Alahmar  1
Affiliations
Review

Role of Oxidative Stress in Male Infertility: An Updated Review

Ahmed T Alahmar. J Hum Reprod Sci. 2019 Jan-Mar.

Abstract

Current evidence links oxidative stress (OS) to male infertility, reduced sperm motility, sperm DNA damage and increased risk of recurrent abortions and genetic diseases. A review of PubMed, Medline, Google Scholar, and Cochrane review databases of published articles from years 2000-2018 was performed focusing on physiological and pathological consequences of reactive oxygen species (ROS), sperm DNA damage, OS tests, and the association between OS and male infertility, pregnancy and assisted reproductive techniques outcomes. Generation of ROS is essential for reproductive function, but OS is detrimental to fertility, pregnancy, and genetic status of the newborns. Further, there is a lack of consensus on selecting OS test, type, and duration of antioxidants treatment as well as on the target patients group. Developing advanced diagnostic and therapeutic options for OS is essential to improve fertility potential and limit genetic diseases transmitted to offspring.

Keywords: Antioxidants; male infertility; oxidative stress; sperm DNA damage.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Sources of reactive oxygen species in the body and their pathological consequences on semen, fertility and health. ROS = Reactive oxygen species, OS = Oxidative stress
See this image and copyright information in PMC

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References

    1. Rowe P, Comhaire FH, Hargreave T. WHO Manual for the Standardized Investigation of the Infertile Couple. Cambridge: Cambridge University Press; 1993.
    1. Agarwal A, Ahmad G, Sharma R. Reference values of reactive oxygen species in seminal ejaculates using chemiluminescence assay. J Assist Reprod Genet. 2015;32:1721–9. - PMC - PubMed
    1. Slade P, O'Neill C, Simpson AJ, Lashen H. The relationship between perceived stigma, disclosure patterns, support and distress in new attendees at an infertility clinic. Hum Reprod. 2007;22:2309–17. - PubMed
    1. Alahmar A. Effect of Vitamin C, Vitamin E, zinc, selenium, and coenzyme Q10 in infertile men with idiopathic oligoasthenozoospermia. Int J Infertil Fetal Med. 2017;8:45–9.
    1. Henkel R, Schill WB. Sperm separation in patients with urogenital infections. Andrologia. 1998;30(Suppl 1):91–7. - PubMed