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Review
. 2019 Mar 25:24:23.
doi: 10.4103/jrms.JRMS_256_18. eCollection 2019.

An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis

Hesam Alizade  1   2 , Saeed Hosseini Teshnizi  3 , Mohsen Azad  1 , Saeed Shojae  1 , Hamed Gouklani  1 , Parivash Davoodian  1 , Reza Ghanbarpour  4
Affiliations
Review

An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis

Hesam Alizade et al. J Res Med Sci. .

Abstract

Background: Diarrheagenic Escherichia coli (DEC) is a common enteric pathogen that causes a wide spectrum of gastrointestinal infections, particularly in developing countries. This is a systematic review and meta-analysis to determine the prevalence of DEC in various geographical regions in Iran.

Materials and methods: English (PubMed, Web of Science, Scopus, Embase, Cochrane Library, and Google Scholar) and Persian (IranMedex, SID, Magiran, and Iran Doc) databases were comprehensively searched from January 1990 to April 2017. Study selection and data extraction were performed by two independent reviewers. After assessing heterogeneity among studies, a random effects model was applied to estimate pooled prevalence. Data analyses were done with the Stata software (version 12.0). This meta-analysis was registered with PROSPERO, number CRD42017070411.

Results: A total of 73 studies with 18068 isolates were eligible for inclusion within the meta-analysis. The results of random effects model showed that the most prevalent DEC pathotypes were enterotoxigenic E. coli (ETEC) (16%; 95% confidence interval [CI]: 11%-23%), enteroaggregative E. coli (11%; 95% CI: 8%-15%), atypical enteropathogenic E. coli (EPEC) (11%; 95% CI: 8%-14%), Shiga toxin-producing E. coli (9%; 95% CI: 6%-13%), diffuse adherent E. coli (6%; 95% CI: 6%-12%), enteroinvasive E. coli (4%; 95% CI: 2%-6%), and typical EPEC (3%; 95% CI: 1%-5%).

Conclusion: This study showed that DEC infections in the Iranian population have low frequency. Our data suggest that the ETEC pathotype can be regarded as one of the most important etiological agents of diarrhea in this country. However, the prevalence of DEC pathotypes is diverse in different regions of Iran.

Keywords: Diarrhea; Escherichia coli; Iran; meta-analysis; systematic review.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of study selection
Figure 2
Figure 2
Relationship between sample size and effect size for included studies
Figure 3
Figure 3
Forest plot of prevalence for seven pathotypes of diarrheagenic Escherichia coli in Iran. Diamonds indicate the 95% confidence interval for each pathotypes
Figure 4
Figure 4
Funnel plot to display publication bias among 73 studies included in meta-analysis
See this image and copyright information in PMC

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