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. 2019 May;17(5):3965-3970.
doi: 10.3892/etm.2019.7454. Epub 2019 Mar 29.

Impact of donor age on liver regeneration and function following adult living donor liver transplantation

Mingyang Li  1 , Zhiqiang Chu  2 , Zhijun Tan  3 , Yanyu Jin  3 , Min Xu  1 , Qian Ji  4
Affiliations

Impact of donor age on liver regeneration and function following adult living donor liver transplantation

Mingyang Li et al. Exp Ther Med. 2019 May.

Abstract

The aim of the present study was to evaluate the impact of donor age on liver function and regeneration following living donor liver transplantation. Donors were divided into an elderly donor group (age >50 years old; n=8) and a young donor group (age <30 years old; n=35). The recipients were also divided into an elderly group (age >50 years old; n=5) and a young group (age <30 years old; n=25). Alanine aminotransferase, aspartate aminotransferase, total bilirubin (TB) and prothrombin time were recorded 1-5 days postoperatively. The liver regeneration ratio (LRR) was recorded 7 and 15 days postoperatively in donors and at 0.5, 1, 3 and 6 months postoperatively in recipients by contrast-enhanced multi-slice spiral computed tomography. Notably, the LRR in the young donor group was significantly increased compared with that in the elderly donor group at 7 days postoperatively (P<0.05). Among recipients, TB in the elderly group was significantly increased compared with that in the young group at 1-5 days postoperatively (P<0.05). The residual liver regeneration rate was decreased and the time of jaundice was prolonged in recipients in the elderly group 7 days postoperatively, but donor age had little impact on the short-term outcome of the residual liver and graft.

Keywords: donor age; hepatic; liver; recipient age; transplantation.

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Figures

Figure 1.
Figure 1.
Liver volume and vascular distribution measured by IQQA in healthy donors. (A) From left to right, different colors represent liver right lobe, left inner lobe and left lateral lobe, respectively. (B) Distribution of liver vein in liver. (C) Distribution of portal vein in liver.
Figure 2.
Figure 2.
Postoperative liver function indices of donors. POD, postoperative day; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TB, total bilirubin; PT, prothrombin time.
Figure 3.
Figure 3.
Postoperative liver function indices of recipients. POD, postoperative day; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TB, total bilirubin; PT, prothrombin time.
See this image and copyright information in PMC

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