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. 2019 Apr;98(16):e14939.
doi: 10.1097/MD.0000000000014939.

Metabolic characteristics of obese children with fatty liver: A STROBE-compliant article

Kanglu Zhao  1   2 , Hongzhen Ju  1 , Haili Wang  2   3
Affiliations

Metabolic characteristics of obese children with fatty liver: A STROBE-compliant article

Kanglu Zhao et al. Medicine (Baltimore). 2019 Apr.

Abstract

To investigate metabolic differences between simple obese children and those comorbid with fatty liver disease.Obese children hospitalized in our center from 2014 to 2016 were included and divided into simple obese group and obese with fatty liver group by ultrasound-based diagnosis of fatty liver. Epidemiology data and serum biochemical studies were recorded. Body Mass Index (BMI) and homeostasis model insulin resistance index (HOMA-IR) were calculated accordingly.A total of 186 obese children were enrolled in this study, including 93 cases of obese children and 93 obese patients' comorbid with fatty liver. The proportion of male, age, waist circumference (WC), BMI, fasting blood-glucose (FBG), glycosylated hemoglobin A1c (HbA1c), fasting insulin (FINS), and HOMA-IR were significantly higher in obese patients with fatty liver (P <.05). Age and BMI were found to be independent risk factors for fatty liver disease (OR >1, P <.05).Among obese children, male and elder patients and individuals with higher uric acid are more susceptible to fatty liver.

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Conflict of interest statement

No author has any conflict of interest to claim.

Figures

Figure 1
Figure 1
Comparison of BMI (A), HOMA-IR (B), and UA (C) in 2 groups. Group A: simple obesity; Group B: obesity with fatty liver.aP <.05. BMI = Body Mass Index, HOMA-IR = homeostasis model insulin resistance index, UA = uric acid.
Figure 2
Figure 2
Association between UA and BMI (A), WC (B), HOMA-IR (C), TC (D). BMI = Body Mass Index, HOMA-IR = homeostasis model insulin resistance index, TC = total cholesterol, UA = uric acid, WC = waist circumference.
See this image and copyright information in PMC

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