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Observational Study
. 2020 Feb;18(2):511-513.
doi: 10.1016/j.cgh.2019.04.035. Epub 2019 Apr 19.

Prevalence of Spontaneous Clearance of Hepatitis C Virus Infection Doubled From 1998 to 2017

Suk Seo  1 , Michael J Silverberg  2 , Leo B Hurley  2 , Joanna Ready  3 , Varun Saxena  4 , David Witt  5 , C Bradley Hare  6 , Jamila H Champsi  4 , Daniel G Korn  7 , Mary Patricia Pauly  8 , Scott Chamberland  9 , Jennifer B Lai  5 , Julia L Marcus  10
Affiliations
Observational Study

Prevalence of Spontaneous Clearance of Hepatitis C Virus Infection Doubled From 1998 to 2017

Suk Seo et al. Clin Gastroenterol Hepatol. 2020 Feb.

Abstract

Strategic planning for hepatitis C virus (HCV) screening and treatment requires up-to-date information on the prevalence of HCV spontaneous clearance. Published estimates of HCV spontaneous clearance range from 15% to 60%.1-3 We conducted an observational study over 20 years to evaluate trends in the prevalence of HCV spontaneous clearance. Our goals were to estimate the proportion of HCV-antibody-positive patients who were viremic, and to identify factors associated with viremia, thus facilitating prediction of the number of patients needing treatment.

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Figures

Figure 1.
Figure 1.. Prevalence of spontaneous clearance of HCV by year of PCR test during 1998–2017.
HCV, hepatitis C virus; Ab, antibody. Solid line displays percent with spontaneous clearance for all patients testing HCV-antibody positive. Dotted and dashed lines display percentage with spontaneous clearance for birth years ≥1965, 1945–1965, and <1945.
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