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. 2019 Apr 20;11(4):887.
doi: 10.3390/nu11040887.

Feralgine™ a New Approach for Iron Deficiency Anemia in Celiac Patients

Laura Giancotti  1 , Valentina Talarico  2 , Giuseppe Antonio Mazza  3 , Santina Marrazzo  4 , Pietro Gangemi  5 , Roberto Miniero  6 , Marco Bertini  7
Affiliations

Feralgine™ a New Approach for Iron Deficiency Anemia in Celiac Patients

Laura Giancotti et al. Nutrients. .

Abstract

Background: Celiac disease (CD) is an immunologically-mediated disorder characterized by duodenal mucosa villi atrophy. Iron absorption is usually reduced in celiac patients making every kind of oral iron treatment unhelpful because of malasorption. Feralgine™ is a new product that has been demonstrated to be more bioavailable. As such, the aim of our study was to evaluate the absorption of Feralgine™ in adult patients with CD.

Methods: Twenty-six adults affected by Iron Deficiency Anemia (IDA), of which 14 were also affected by CD and 12 were not affected by CD, were enrolled. An oral iron absorption test (OIAT) was performed in each patient by administrating Feralgine™, and serum iron was evaluated at baseline (T0) and after 2 h (T1) from the oral iron ingestion.

Results: The OIAT was well tolerated in all patients, and, surprisingly, an equivalent statistically significant improvement in serum iron occurred in the two groups of patients (IDA plus CD: T0 = 28.21 µg/dL vs. T1 = 94.14 µg/dL p = 0.004 and IDA without CD: T0 = 34.91 µg/dL vs. T1 = 118.83 µg/dL, p = 0.0003).

Conclusions: These results demonstrated the high absorption of Feralgine™ in celiac patients, confirming our previous data obtained with Ferrous Bysglicinate in children with CD.

Keywords: celiac disease; ferrous bisglycinate chelate alginate; iron deficiency anemia; oral iron absorption test.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Serum iron levels in all patients.
Figure 2
Figure 2
Changes in serum iron levels in celiac disease (CD) patients with iron deficiency anemia (IDA).
Figure 3
Figure 3
Changes in serum iron levels in IDA patients without CD.
See this image and copyright information in PMC

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