Oral and Psychological Alterations in Haemophiliac Patients

Luca Fiorillo^{1

2}, Rosa De Stefano³, Gabriele Cervino⁴, Salvatore Crimi⁵, Alberto Bianchi⁶, Paola Campagna⁷, Alan Scott Herford⁸, Luigi Laino⁹, Marco Cicciù¹⁰

Affiliations

¹ Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy. lucafiorillo@live.it.
² Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", 80121 Naples, Italy. lucafiorillo@live.it.
³ Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy. rsdestefano@libero.it.
⁴ Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy. gcervino@unime.it.
⁵ Department of Surgical and Biomedical Sciences, Catania University, 95123 Catania, Italy. torecrimi@gmail.com.
⁶ Department of Surgical and Biomedical Sciences, Catania University, 95123 Catania, Italy. alberto.bianchi@unict.it.
⁷ Department of Surgical and Biomedical Sciences, Catania University, 95123 Catania, Italy. paolacampagna91@gmail.com.
⁸ Department of Maxillofacial Surgery, Loma Linda University, Loma Linda, CA 92354, USA. aherford@llu.edu.
⁹ Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", 80121 Naples, Italy. luigi.laino@unicampania.it.
¹⁰ Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy. acromarco@yahoo.it.

PMID: 31010003
PMCID: PMC6631232
DOI: 10.3390/biomedicines7020033

Review

Oral and Psychological Alterations in Haemophiliac Patients

Luca Fiorillo et al. Biomedicines. 2019.

. 2019 Apr 20;7(2):33.

doi: 10.3390/biomedicines7020033.

Authors

Luca Fiorillo^{1

2}, Rosa De Stefano³, Gabriele Cervino⁴, Salvatore Crimi⁵, Alberto Bianchi⁶, Paola Campagna⁷, Alan Scott Herford⁸, Luigi Laino⁹, Marco Cicciù¹⁰

Affiliations

¹ Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy. lucafiorillo@live.it.
² Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", 80121 Naples, Italy. lucafiorillo@live.it.
³ Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy. rsdestefano@libero.it.
⁴ Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy. gcervino@unime.it.
⁵ Department of Surgical and Biomedical Sciences, Catania University, 95123 Catania, Italy. torecrimi@gmail.com.
⁶ Department of Surgical and Biomedical Sciences, Catania University, 95123 Catania, Italy. alberto.bianchi@unict.it.
⁷ Department of Surgical and Biomedical Sciences, Catania University, 95123 Catania, Italy. paolacampagna91@gmail.com.
⁸ Department of Maxillofacial Surgery, Loma Linda University, Loma Linda, CA 92354, USA. aherford@llu.edu.
⁹ Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", 80121 Naples, Italy. luigi.laino@unicampania.it.
¹⁰ Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy. acromarco@yahoo.it.

PMID: 31010003
PMCID: PMC6631232
DOI: 10.3390/biomedicines7020033

Abstract

Haemophiliacs are hereditary coagulopathies whose basic anomaly consists of the quantitative or qualitative alteration of one or more plasma proteins in the coagulation system. The objective of this review is to analyse all risk factors, predispositions and alterations to the oral-maxillofacial district in patients with haemophilia. The broader assessment also includes the psychological aspects that could affect the treatment and maintenance of oral conditions. The study takes into consideration all the works in the literature in the last 10 years. Works that present oral, dental and psychological changes in haemophilia patients have been combined. A total of 16 studies were analysed carefully evaluating and explaining all the alterations and risk factors that this disease provides. The aim of the review is to report all the anomalies reported in the literature for these patients, and to direct and update the clinician in the treatment of haemophilia patients.

Keywords: dental risk factor; haemophilia; oral alterations; psychological conditions.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram.

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References

1. Harold R.R. Haemophilia and Haemostasis: A Case-Based Approach to Management. Wiley-Blackwell; Hoboken, NJ, USA: 2008.
1. Green D. Haemophilia and Von Willebrand Disease. Academic Press; Cambridge, MA, USA: 2018.
1. Peyvandi F., Garagiola I., Young G. The past and future of haemophilia: Diagnosis, treatments, and its complications. Lancet. 2016;388:187–197. doi: 10.1016/S0140-6736(15)01123-X. - DOI - PubMed
1. Brody H. Haemophilia. Nature. 2014;515:S157. doi: 10.1038/515S157a. - DOI - PubMed
1. Bertamino M., Riccardi F., Banov L., Svahn J., Molinari A.C. Hemophilia Care in the Pediatric Age. J. Clin. Med. 2017;6:54. doi: 10.3390/jcm6050054. - DOI - PMC - PubMed

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Oral and Psychological Alterations in Haemophiliac Patients

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Oral and Psychological Alterations in Haemophiliac Patients

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