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Review
. 2019 Apr 20;11(4):894.
doi: 10.3390/nu11040894.

The Good, the Bad, and the Ugly of Pregnancy Nutrients and Developmental Programming of Adult Disease

Chien-Ning Hsu  1   2 , You-Lin Tain  3   4
Affiliations
Review

The Good, the Bad, and the Ugly of Pregnancy Nutrients and Developmental Programming of Adult Disease

Chien-Ning Hsu et al. Nutrients. .

Abstract

Maternal nutrition plays a decisive role in developmental programming of many non-communicable diseases (NCDs). A variety of nutritional insults during gestation can cause programming and contribute to the development of adult-onset diseases. Nutritional interventions during pregnancy may serve as reprogramming strategies to reverse programming processes and prevent NCDs. In this review, firstly we summarize epidemiological evidence for nutritional programming of human disease. It will also discuss evidence from animal models, for the common mechanisms underlying nutritional programming, and potential nutritional interventions used as reprogramming strategies.

Keywords: developmental origins of health and disease (DOHaD); gut microbiota; non-communicable disease; nutrient-sensing signal; nutrition; oxidative stress; pregnancy; reprogramming.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic illustration of the good, the bad, and the ugly sides of nutritional programming involved in developmental programming of health and disease.
See this image and copyright information in PMC

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