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Comment
. 2019 May;139(5):995-996.
doi: 10.1016/j.jid.2019.01.026. Epub 2019 Apr 19.

Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight

Natalie Garzorz-Stark  1 , Kilian Eyerich  2
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Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight

Natalie Garzorz-Stark et al. J Invest Dermatol. 2019 May.
Free article

Abstract

Psoriasis is a T helper type 17-mediated immune disease. Initial triggers that lead to T helper type 17 production and inflammatory cell recruitment into skin are being delineated. Autoantigens that stimulate T helper type 17 cells are also being identified. A new and important piece of the puzzle indicates that keratinocytes not only amplify inflammation, but that they are essential for a full-blown IL-17-mediated psoriatic phenotype in mice.

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