Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jun;46(2):327-347.
doi: 10.1016/j.clp.2019.02.012. Epub 2019 Mar 30.

Drugs for the Prevention and Treatment of Sepsis in the Newborn

Affiliations
Review

Drugs for the Prevention and Treatment of Sepsis in the Newborn

Sagori Mukhopadhyay et al. Clin Perinatol. 2019 Jun.

Abstract

Antimicrobial medications are the most commonly used medications in the neonatal intensive care unit. Antibiotics are used for infection prophylaxis, empiric treatment, and definitive treatment of confirmed infection. The choice of medication should be informed by the epidemiology and microbiology of infection in specific clinical scenarios and by the clinical condition of the infant. Understanding evolving pathogen susceptibility to antimicrobials and key pharmacotherapy determinants in neonates can inform optimal antibiotic use.

Keywords: Antibiotics; Newborn; Prophylaxis; Sepsis.

PubMed Disclaimer

References

    1. Flannery DD, Ross RK, Mukhopadhyay S, Tribble AC, Puopolo KM, Gerber JS. Temporal trends and center variation in early antibiotic use among premature infants. JAMA Network Open. 2018;1(1):e180164–e180164. - PMC - PubMed
    1. Hsieh EM, Hornik CP, Clark RH, et al. Medication use in the neonatal intensive care unit. Am J Perinatol. 2014;31(9):811–821. - PMC - PubMed
    1. Cailes B, Kortsalioudaki C, Buttery J, et al. Antimicrobial resistance in UK neonatal units: neonIN infection surveillance network. Arch Dis Child Fetal Neonatal Ed. 2018;103(5):F474–F478. - PubMed
    1. Dallefeld S, Hornik CD, Zimmerman K, Cohen-wolkoweiz M. Antibiotic dosing considerations for term and preterm infants In: Bentiz WE, Smith PB, eds. Neonatology questions and controversies: Infectious disease and pharmacology. 1st ed. Elsevier; 2018:167.
    1. Pacifici GM. Clinical pharmacokinetics of penicillins, cephalosporins and aminoglycosides in the neonate: A review. Pharmaceuticals (Basel). 2010;3(8):2568–2591. - PMC - PubMed

Publication types

Substances