Drugs for the Prevention and Treatment of Sepsis in the Newborn
- PMID: 31010563
- PMCID: PMC6485941
- DOI: 10.1016/j.clp.2019.02.012
Drugs for the Prevention and Treatment of Sepsis in the Newborn
Abstract
Antimicrobial medications are the most commonly used medications in the neonatal intensive care unit. Antibiotics are used for infection prophylaxis, empiric treatment, and definitive treatment of confirmed infection. The choice of medication should be informed by the epidemiology and microbiology of infection in specific clinical scenarios and by the clinical condition of the infant. Understanding evolving pathogen susceptibility to antimicrobials and key pharmacotherapy determinants in neonates can inform optimal antibiotic use.
Keywords: Antibiotics; Newborn; Prophylaxis; Sepsis.
Copyright © 2019 Elsevier Inc. All rights reserved.
References
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- Cailes B, Kortsalioudaki C, Buttery J, et al. Antimicrobial resistance in UK neonatal units: neonIN infection surveillance network. Arch Dis Child Fetal Neonatal Ed. 2018;103(5):F474–F478. - PubMed
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- Dallefeld S, Hornik CD, Zimmerman K, Cohen-wolkoweiz M. Antibiotic dosing considerations for term and preterm infants In: Bentiz WE, Smith PB, eds. Neonatology questions and controversies: Infectious disease and pharmacology. 1st ed. Elsevier; 2018:167.
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