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Case Reports
. 2019 Apr 10;14(6):775-777.
doi: 10.1016/j.radcr.2019.03.032. eCollection 2019 Jun.

Pulmonary alveolar microlithiasis diagnosed with radiography, CT, and bone scintigraphy

Emad Alkhankan  1 , Hasan Yamin  1 , Hazim Bukamur  1 , Fadi Alkhankan  1   2 , Yousef Shweihat  1 , Fuad Zeid  1
Affiliations
Case Reports

Pulmonary alveolar microlithiasis diagnosed with radiography, CT, and bone scintigraphy

Emad Alkhankan et al. Radiol Case Rep. .

Abstract

Pulmonary alveolar microlithiasis is rare disease characterized by accumulation of calcium phosphate microlithis in the alveoli. The pathogenesis relates to mutation in the gene SLC34A2 (solute carrier family 34 member 2) located on chromosome 4p15.2, which produces a defective sodium-phosphate cotransporter in alveolar epithelial type-2 cells, making these cells unable to clear phosphorus released during recycling of surfactant [1].

Keywords: Alveolar microlithiasis; Bone scan scintography of the lung; Hypoxemia; Interstitial lung disease; Lung calcification; SLC34A2 gene.

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Figures

Fig 1
Fig. 1
Chest X-ray showing diffuse bilateral infiltartes.
Fig 2
Fig. 2
CT Scan of the chest without contrast showing diffuse calcification with septal thickening.
Fig 3
Fig. 3
CT Scan of the chest without contrast showing diffuse ground glass attenuation with septal thickening.
Fig 4
Fig. 4
Technetium 99m-methylene diphosphonate (Tc99m-MDP) showing diffuse radiotracer uptake.
See this image and copyright information in PMC

References

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