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Case Reports
. 2019 Mar 27:28:116-119.
doi: 10.1016/j.gore.2019.03.016. eCollection 2019 May.

Co-occurring substance use disorder: The impact on treatment adherence in women with locally advanced cervical cancer

Lisa A Rubinsak  1 , Mishka Terplan  2 , Caitlin E Martin  2 , Emma C Fields  3 , William P McGuire  4 , Sarah M Temkin  1
Affiliations
Case Reports

Co-occurring substance use disorder: The impact on treatment adherence in women with locally advanced cervical cancer

Lisa A Rubinsak et al. Gynecol Oncol Rep. .

Abstract

The purpose of this study was to identify the prevalence of substance use disorder and its association with adherence to treatment and survival in locally advanced cervical cancer patients treated with primary radiation therapy. This is a retrospective case series of locally advanced cervical cancer patients with substance use disorder in a single academic institution treated with radiation therapy between 2005 and 2016. Substance use disorder was identified through chart review. Those with substance use disorder were compared to those without in regards to demographics, Charlson comorbidity index, treatment details and outcomes. Of the 129 patients with locally advanced cervical cancer, 16 (12.4%) were identified as having substance use disorder. Patients with substance use disorder were younger (42.1 years vs 51.5 years, p = .013) and more likely to be smokers (81.3% vs 42.5%, p = .004). The majority of patients with substance use disorder received concurrent chemotherapy (93.8%) and brachytherapy in addition to external beam radiation therapy (81.3%). There was no significant difference in days to completion of radiation therapy between patients with and without substance use disorder. Radiation dose received, toxicities and survival were similar between groups. Among cervical cancer patients receiving treatment with radiation therapy, substance use disorder was not associated with poorer adherence, longer radiation treatment times or a difference in total dose of radiation received. Our experience demonstrates that patients with substance use disorder are able to adhere to complex, multimodal treatment plans resulting in similar cancer specific outcomes compared to patients without substance use disorder.

Keywords: Cervical cancer; Substance use disorder; Treatment adherence.

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Figures

Fig. 1
Fig. 1
Consort diagram for participants.
Fig. 2
Fig. 2
Survival outcomes stratified by substance use disorder (SUD) comorbidity. a. progression free survival (PFS) in months b. overall survival (OS) in months.
See this image and copyright information in PMC

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References

    1. Baillargeon J., Kuo Y.F., Lin Y.L., Raji M.A., Singh A., Goodwin J.S. Effect of mental disorders on diagnosis, treatment, and survival of older adults with colon cancer. J. Am. Geriatr. Soc. 2011;59:1268–1273. - PMC - PubMed
    1. Chang G., Meadows M.E., Jones J.A., Antin J.H., Orav E.J. Substance use and survival after treatment for chronic myelogenous leukemia (CML) or myelodysplastic syndrome (MDS) Am. J. Drug Alcohol Abuse. 2010;36:1–6. - PMC - PubMed
    1. Chang C.K., Hayes R.D., Broadbent M.T., Hotopf M., Davies E., Moller H. A cohort study on mental disorders, stage of cancer at diagnosis and subsequent survival. BMJ Open. 2014;4 - PMC - PubMed
    1. Chhatre S., Metzger D.S., Malkowicz S.B., Woody G., Jayadevappa R. Substance use disorder and its effects on outcomes in men with advanced-stage prostate cancer. Cancer. 2014;120:3338–3345. - PMC - PubMed
    1. Childers J.W., King L.A., Arnold R.M. Chronic pain and risk factors for opioid misuse in a palliative care clinic. Am. J. Hosp. Palliat. Care. 2015;32:654–659. - PubMed

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