Sigma-1 Receptor Antagonists Haloperidol and Chlorpromazine Modulate the Effect of Glutoxim on Na+ Transport in Frog Skin

Abstract

Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na⁺ transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine attenuates the stimulatory effect of glutoxim on the Na⁺ transport. The results suggest the possible involvement of the sigma-1 receptors in the regulation of Na⁺ transport in frog skin epithelium by glutoxim.