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. 2019 May;484(1):63-65.
doi: 10.1134/S1607672919010186. Epub 2019 Apr 22.

Sigma-1 Receptor Antagonists Haloperidol and Chlorpromazine Modulate the Effect of Glutoxim on Na+ Transport in Frog Skin

Z I Krutetskaya  1 , A V Melnitskaya  2 , V G Antonov  2 , A D Nozdrachev  2
Affiliations

Sigma-1 Receptor Antagonists Haloperidol and Chlorpromazine Modulate the Effect of Glutoxim on Na+ Transport in Frog Skin

Z I Krutetskaya et al. Dokl Biochem Biophys. 2019 May.

Abstract

Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+ transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine attenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possible involvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.

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