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. 2019 Apr 23;14(4):e0215538.
doi: 10.1371/journal.pone.0215538. eCollection 2019.

The association between neck adiposity and long-term outcome

Sigal Tal  1   2 , Ilya Litovchik  2   3 , Miriam M Klar  1   2 , Hillel S Maresky  1   2   4 , Noam Grysman  2   5 , Itay Wiser  2   6 , Itzhak Vitkon-Barkay  2   3 , Gil Marcus  2   3 , Oran Tzuman  2   7 , David Pereg  2   8 , Victoria Rum  2   3 , Tomer Ziv-Baran  9 , Shmuel Fuchs  2   3 , Sa'ar Minha  2   3
Affiliations

The association between neck adiposity and long-term outcome

Sigal Tal et al. PLoS One. .

Abstract

Anthropometric indices of obesity (e.g. body mass index, waist circumference and neck circumference) are associated with poor long-term cardiovascular outcome. Prior studies have associated neck circumference and central body adiposity. We explored the association between neck fat volume (NFV) and long-term cardiovascular outcome. The study provides a retrospective analysis of all patients undergoing computerized tomography angiography for suspected cerebrovascular accident between January and December 2013. NFV was assessed by three dimensional reconstructions and was adjusted to height to account for differences in body sizes, thus yielding the NFV/height ratio (NHR). Univariate and multivariate analysis were utilized to explore the association between various indices including NHR and all-cause mortality. The analysis included 302 patients. The average age was 61.9±14.3 years, 60.6% of male gender. Diabetes mellitus, hypertension and cardiovascular disease were frequent in 31.5%, 69.9%, and 72.2% of patients, respectively. The median NHR was 492.53cm2 [IQR 393.93-607.82]. Median follow up time was 41.2 months, during which 40 patients (13.2%) died. Multivariate analysis adjusting for age, sex, and diabetes mellitus indicated an independent association between the upper quartile of NHR and all-cause mortality (hazard ratio = 2.279; 95% CI = 1.209-4.299; p = .011). NHR is a readily available anthropometric index which significantly correlated with poor long-term outcome. Following validation in larger scale studies, this index may serve a risk stratifying tool for cardiovascular disease and future outcome.

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Conflict of interest statement

HSM is the owner of Visionary Corp., in Toronto, Canada, and MMK is affiliated with this organization. Visionary Corp received a grant from NVIDIA Corporation, but had no influence in the current study. The authors' affiliation with Visionary Corp is completely independent of the current study. HSM, MMK, and ST have a patent pending related to another study conducted at the same institution; this is completely independent of and had no influence over the current study. These do not alter the authors' adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.

Figures

Fig 1
Fig 1. Kaplan-Meier analysis for all-cause mortality stratified by NHR quartiles.
See this image and copyright information in PMC

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