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Comment
. 2019 Sep;70(3):1058-1060.
doi: 10.1002/hep.30673. Epub 2019 May 23.

The Gut-Liver Axis in Primary Sclerosing Cholangitis: Are Pathobionts the Missing Link?

Steven P O'Hara  1 , Nicholas F LaRusso  1
Affiliations
Comment

The Gut-Liver Axis in Primary Sclerosing Cholangitis: Are Pathobionts the Missing Link?

Steven P O'Hara et al. Hepatology. 2019 Sep.
No abstract available

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Conflict of interest statement

Potential conflict of interest: Nothing to report.

Figures

FIG. 1.
FIG. 1.
Using mice recolonized with human fecal samples from PSC/UC (A), UC, or healthy control patients and a monolayer culture system of human intestinal organoids, Nakamoto et al., found that the pathobiont, Klebsiella pneumoniae, promoted bacterial translocation via intestinal epithelial cell barrier dysfunction (B). They further identified three bacterial species that translocated to the mesenteric lymph nodes (MLN) of recolonized mice (C). The bacteria and/or bacterial endotoxins from these three microbes were delivered to the liver (D) and cooperatively promoted TH17 priming (E). In the TH17 primed liver, a second trigger, such as the experimentally induced injury with DDC or taurocholic acid, promoted severe hepatobiliary injury.
See this image and copyright information in PMC

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