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Review
. 2019 Apr 22;20(8):1959.
doi: 10.3390/ijms20081959.

Crosstalk between Oxidative Stress and Tauopathy

Md Mamunul Haque  1 , Dhiraj P Murale  2 , Yun Kyung Kim  3   4 , Jun-Seok Lee  5   6
Affiliations
Review

Crosstalk between Oxidative Stress and Tauopathy

Md Mamunul Haque et al. Int J Mol Sci. .

Abstract

Tauopathy is a collective term for neurodegenerative diseases associated with pathological modifications of tau protein. Tau modifications are mediated by many factors. Recently, reactive oxygen species (ROS) have attracted attention due to their upstream and downstream effects on tauopathy. In physiological conditions, healthy cells generate a moderate level of ROS for self-defense against foreign invaders. Imbalances between ROS and the anti-oxidation pathway cause an accumulation of excessive ROS. There is clear evidence that ROS directly promotes tau modifications in tauopathy. ROS is also highly upregulated in the patients' brain of tauopathies, and anti-oxidants are currently prescribed as potential therapeutic agents for tauopathy. Thus, there is a clear connection between oxidative stress (OS) and tauopathies that needs to be studied in more detail. In this review, we will describe the chemical nature of ROS and their roles in tauopathy.

Keywords: oxidative stress; reactive oxygen species; tauopathy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Oxidative stress-mediated tauopathy.
Figure 2
Figure 2
Electronic configuration of reactive oxygen species (ROS).
Figure 3
Figure 3
Standard reduction potentials of ROS formation via energy or electron transfer reactions of molecular oxygen.
Figure 4
Figure 4
Physiological condition versus tauopathy condition by oxidative stress generation.
See this image and copyright information in PMC

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