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Meta-Analysis
. 2019 Apr 23;19(1):372.
doi: 10.1186/s12885-019-5585-5.

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Xue Chao  1   2 , Kai Chen  1   2 , Jiayi Zeng  3 , Zhuofei Bi  1   4 , Mingyan Guo  1   5 , Yi Chen  1   2 , Yandan Yao  1   2 , Wei Wu  1   2 , Shi Liang  1   2 , Yan Nie  6   7
Affiliations
Meta-Analysis

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Xue Chao et al. BMC Cancer. .

Abstract

Background: As the efficacy of radiotherapy and chemotherapy for treatment of phyllodes tumors (PTs) remains unclear, this study aimed to review all available data and evaluate the roles of radiotherapy and chemotherapy in PT treatment.

Methods: We performed a comprehensive search of databases, including PubMed, Web of Science and the Cochrane Library. The outcomes of interest included the local recurrence (LR) rate, metastasis rate, disease-free survival rate and overall survival rate.

Results: Seventeen studies enrolling 696 patients were included in this random effect meta-analysis. Subgroup analysis and meta-regression were also conducted to determine study heterogeneity. A pooled local recurrence rate of 8% (95% CI: 1-22%) was observed with a statistical heterogeneity of I2 = 86.6% (p < 0.01) for radiotherapy. This was lower than the recurrence rate of 12% for simple surgical treatment (95% CI: 7-18%). Meta-regression analysis found that surgical margin status was the main source of heterogeneity (p = 0.04). The metastasis rate of 4% (95% CI: 0-11%) for patients receiving radiotherapy without significant heterogeneity was also lower than the rate for the simple surgery group (8, 95% CI: 3-15%). The available data for chemotherapy were too limited to support meta-analysis. Accordingly, we offer a pure review of these data.

Conclusion: Our findings suggest that radiotherapy is effective in achieving local disease control and preventing metastasis.

Keywords: Chemotherapy; Meta-analysis; Phyllodes tumors; Radiotherapy.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

This study involved the use of existing collections of data or records that contain only non-identifiable data. Thus, ethics approval is not needed. Written, informed consent was provided by all participants in each of the studies included in this individual patient meta-analysis.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flow diagram of the literature search
Fig. 2
Fig. 2
Meta-analysis of local recurrence rate of patients treated with radiotherapy (random model)
See this image and copyright information in PMC

References

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