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. 2019 Apr 23;19(1):121.
doi: 10.1186/s12887-019-1492-9.

Respiratory severity score as a predictive factor for severe bronchopulmonary dysplasia or death in extremely preterm infants

Young Hwa Jung  1 , Jinhee Jang  1 , Han-Suk Kim  2 , Seung Han Shin  3 , Chang Won Choi  1 , Ee-Kyung Kim  3 , Beyong Il Kim  1
Affiliations

Respiratory severity score as a predictive factor for severe bronchopulmonary dysplasia or death in extremely preterm infants

Young Hwa Jung et al. BMC Pediatr. .

Erratum in

Abstract

Background: Despite significant advances in neonatology, bronchopulmonary dysplasia (BPD) remains the most common cause of serious morbidity and mortality in premature infants. The aim of the present study was to determine associations between the respiratory severity score (RSS) with death or BPD in premature infants.

Methods: This was a retrospective study conducted between January 2010 and December 2014. We enrolled preterm infants with a gestational age of less than 28 weeks who were supported by mechanical ventilation for more than a week during the first 4 weeks of life. We collected the RSS scores on day of life 2, 7, 14, 21 and 28. The correlations between postnatal RSSs and death or severe BPD were analyzed using multivariate logistic regression.

Results: Of the 138 eligible infants, 66 infants (47.8%) either died or developed severe BPD. The RSS cut-off values for predicting severe BPD or death were 3.0 for postnatal day (PND) 14 with an odds ratio (OR) of 11.265 (p = 0.0006, 95% confidence interval (CI), 2.842 to 44.646), 3.6 for PND 21 with an OR of 15.162 (p = 0.0003, 95% CI, 3.467 to 66.316), and 3.24 for PND 28 with an OR of 10.713 (p = 0.0005, 95% CI, 2.825 to 40.630).

Conclusion: Strong correlations were observed between the RSSs on PND 14, 21, and 28 and death or subsequent severe BPD. The RSS could provide a simple estimate of severe BPD or death., Further research with a larger study population is necessary to validate the usefulness of the RSS for predicting severe BPD or death.

Keywords: Bronchopulmonary dysplasia; Neonatal intensive care; Premature infant; Respiratory severity score; Ventilatory support.

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Conflict of interest statement

Ethics approval and consent to participate

The Institutional Review Board of Seoul National University Hospital approved the collection and use of the clinical information of the patients for research purposes before the investigation was started and waived the requirement for informed consent (IRB No. 1602–026-739).

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Flow diagram of our study population
See this image and copyright information in PMC

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