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Comment
. 2019 Apr 22;29(8):R289-R292.
doi: 10.1016/j.cub.2019.03.015.

Cell Biology: The Health Hazards of Super-Sizing

Clotilde Cadart  1 , Rebecca Heald  2
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Cell Biology: The Health Hazards of Super-Sizing

Clotilde Cadart et al. Curr Biol. .
Free article

Abstract

Cells typically occupy a narrow range of sizes according to their type. A new study reveals that cells grown to gigantic proportions fail to synthesize sufficient macromolecules, resulting in cytoplasm dilution and a loss of fitness reminiscent of old cells.

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  • Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence.
    Neurohr GE, Terry RL, Lengefeld J, Bonney M, Brittingham GP, Moretto F, Miettinen TP, Vaites LP, Soares LM, Paulo JA, Harper JW, Buratowski S, Manalis S, van Werven FJ, Holt LJ, Amon A. Neurohr GE, et al. Cell. 2019 Feb 21;176(5):1083-1097.e18. doi: 10.1016/j.cell.2019.01.018. Epub 2019 Feb 7. Cell. 2019. PMID: 30739799 Free PMC article.

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