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Comment
. 2019 Apr 22;29(8):R297-R299.
doi: 10.1016/j.cub.2019.03.008.

Selective Autophagy: RNA Comes from the Vault to Regulate p62/SQSTM1

Terje Johansen  1
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Selective Autophagy: RNA Comes from the Vault to Regulate p62/SQSTM1

Terje Johansen. Curr Biol. .
Free article

Abstract

A new study shows that the oligomerization of p62/Sequestosome-1 (SQSTM1) - a selective autophagy receptor and signaling adapter - is regulated directly by vault RNA. This riboregulation negatively affects the aggregation state of p62 and thereby its autophagic degradation and its role as a selective autophagy receptor.

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  • The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy.
    Horos R, Büscher M, Kleinendorst R, Alleaume AM, Tarafder AK, Schwarzl T, Dziuba D, Tischer C, Zielonka EM, Adak A, Castello A, Huber W, Sachse C, Hentze MW. Horos R, et al. Cell. 2019 Feb 21;176(5):1054-1067.e12. doi: 10.1016/j.cell.2019.01.030. Epub 2019 Feb 14. Cell. 2019. PMID: 30773316

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