Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Feb 13;11(2):e4068.
doi: 10.7759/cureus.4068.

Tetrasomy 8 Associated with a Poor Prognosis in Acute Monoblastic Leukemia: A Case Report

Fady Farag  1 , Rewais Morcus  1 , Preethi Ramachandran  2 , Karan Josan  2 , Jen Chin Wang  2
Affiliations
Case Reports

Tetrasomy 8 Associated with a Poor Prognosis in Acute Monoblastic Leukemia: A Case Report

Fady Farag et al. Cureus. .

Abstract

We report a case of a 47-year-old male from West Africa who presented with sepsis and was found to have acute monoblastic leukemia associated with tetrasomy 8 detected on bone marrow samples. This was the only chromosomal abnormality found. Tetrasomy 8 is a rare genetic finding that has been reported in acute myeloid leukemia (AML), predominantly the monocytic lineage. It carries a poor prognosis with a high mortality rate.

Keywords: acute myeloid leukemia; aml; karyotyping; poor prognosis; tetrasomy 8.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Peripheral Blood Smear Picture
Figure 2
Figure 2. Bone Marrow Aspiration Showing Monoblasts
Monoblasts are the largest blasts of all the hematopoeitic cell lines present in the bone marrow. They have a large, round, centrally-placed nucleus with soft, fine-stranded chromatin. They normally have a single, large, prominent nucleolus. The cytoplasm is very generous and has a fine, grainy texture.
Figure 3
Figure 3. Fluorescence In Situ Hybridization Results
Note in (d) three green dots representing three copies of RUNX1T1 and two orange dots representing RUNX1
Figure 4
Figure 4. Karyotype of the Patient Showing Tetrasomy of Chromosome 8
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Trisomy 8 in leukemia: a GCRI experience. Bakshi SR, Brahmbhatt MM, Trivedi PJ, et al. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385163/ Indian J Hum Genet. 2012;18:106–108. - PMC - PubMed
    1. Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis. Tsirigotis P, Papageorgiou S, Abatzis D, et al. https://www.sciencedirect.com/science/article/pii/S0165460804006417. Cancer Genet Cytogenet. 2005;161:78–81. - PubMed
    1. Tetrasomy 8 as a clonal anomaly in myeloid neoplasias. Trautmann U, Gramatzki M, Krauss M, Friz A, Liehr T, Gebhart E. https://www.cancergeneticsjournal.org/article/0165-4608(94)90123-6/abstract Cancer Genet. 1994;72:101–104. - PubMed
    1. Tetrasomy 8 is associated with a major cellular proliferative advantage and a poor prognosis: two cases of myeloid hematologic disorders and review of the literature. Yan J, Marceau D, Drouin R. https://www.sciencedirect.com/science/article/pii/S0165460800003526. Cancer Genet Cytogenet. 2001;125:14–20. - PubMed
    1. Cytogenetic and FISH investigations on tetrasomy 8 in ANLL. La Starza R, Crescenzi B, Matteucci C, Martelli MF, Mecucci C. https://www.cancergeneticsjournal.org/article/0165-4608(94)00120-Z/fulltext. Cancer Genet Cytogenet. 1995;79:182–185. - PubMed

Publication types

LinkOut - more resources