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Case Reports
. 2019 Feb 13;11(2):e4068.
doi: 10.7759/cureus.4068.

Tetrasomy 8 Associated with a Poor Prognosis in Acute Monoblastic Leukemia: A Case Report

Fady Farag  1 , Rewais Morcus  1 , Preethi Ramachandran  2 , Karan Josan  2 , Jen Chin Wang  2
Affiliations
Case Reports

Tetrasomy 8 Associated with a Poor Prognosis in Acute Monoblastic Leukemia: A Case Report

Fady Farag et al. Cureus. .

Abstract

We report a case of a 47-year-old male from West Africa who presented with sepsis and was found to have acute monoblastic leukemia associated with tetrasomy 8 detected on bone marrow samples. This was the only chromosomal abnormality found. Tetrasomy 8 is a rare genetic finding that has been reported in acute myeloid leukemia (AML), predominantly the monocytic lineage. It carries a poor prognosis with a high mortality rate.

Keywords: acute myeloid leukemia; aml; karyotyping; poor prognosis; tetrasomy 8.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Peripheral Blood Smear Picture
Figure 2
Figure 2. Bone Marrow Aspiration Showing Monoblasts
Monoblasts are the largest blasts of all the hematopoeitic cell lines present in the bone marrow. They have a large, round, centrally-placed nucleus with soft, fine-stranded chromatin. They normally have a single, large, prominent nucleolus. The cytoplasm is very generous and has a fine, grainy texture.
Figure 3
Figure 3. Fluorescence In Situ Hybridization Results
Note in (d) three green dots representing three copies of RUNX1T1 and two orange dots representing RUNX1
Figure 4
Figure 4. Karyotype of the Patient Showing Tetrasomy of Chromosome 8
See this image and copyright information in PMC

References

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