Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

Jessica L Dunne¹, Sarah J Richardson², Mark A Atkinson³, Maria E Craig⁴, Knut Dahl-Jørgensen^{5

6}, Malin Flodström-Tullberg⁷, Heikki Hyöty^{8

9}, Richard E Lloyd¹⁰, Noel G Morgan¹¹, Alberto Pugliese^{12

13

14}

Affiliations

¹ JDRF, 26 Broadway, 14th Floor, New York, NY, 10004, USA. JDunne@JDRF.org.
² Institute of Biomedical and Clinical Science, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK. S.Richardson@exeter.ac.uk.
³ Departments of Pathology and Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.
⁴ School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
⁵ Department of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.
⁶ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
⁷ Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
⁸ Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
⁹ Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.
¹⁰ Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
¹¹ Institute of Biomedical and Clinical Science, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK.
¹² Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
¹³ Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, FL, USA.
¹⁴ Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.

PMID: 31016358
DOI: 10.1007/s00125-019-4873-6

Comment

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

Jessica L Dunne et al. Diabetologia. 2019 Jun.

. 2019 Jun;62(6):1100-1103.

doi: 10.1007/s00125-019-4873-6. Epub 2019 Apr 23.

Authors

Affiliations

¹ JDRF, 26 Broadway, 14th Floor, New York, NY, 10004, USA. JDunne@JDRF.org.
² Institute of Biomedical and Clinical Science, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK. S.Richardson@exeter.ac.uk.
³ Departments of Pathology and Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.
⁴ School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
⁵ Department of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.
⁶ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
⁷ Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
⁸ Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
⁹ Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.
¹⁰ Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
¹¹ Institute of Biomedical and Clinical Science, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK.
¹² Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
¹³ Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, FL, USA.
¹⁴ Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA.

PMID: 31016358
DOI: 10.1007/s00125-019-4873-6

No abstract available

Keywords: Antiviral agents; Clinical trials; DiViD; Enterovirus; Islet; nPOD.

PubMed Disclaimer

Comment on

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.
Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, Morgan NG, Pugliese A. Dunne JL, et al. Diabetologia. 2019 May;62(5):744-753. doi: 10.1007/s00125-019-4811-7. Epub 2019 Jan 23. Diabetologia. 2019. PMID: 30675626 Free PMC article. Review.
Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence.
Skog O, Klingel K, Roivainen M, Korsgren O. Skog O, et al. Diabetologia. 2019 Jun;62(6):1097-1099. doi: 10.1007/s00125-019-4841-1. Epub 2019 Feb 27. Diabetologia. 2019. PMID: 30810767 No abstract available.

References

1. Skog O, Klingel K, Roivainen M, Korsgren O (2019) Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Diabetologia. https://doi.org/10.1007/s00125-019-4841-1
1. Dunne JL, Richardson SJ, Atkinson MA et al (2019) Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes. Diabetologia 62(5):744–753. https://doi.org/10.1007/s00125-019-4811-7 - DOI - PubMed - PMC
1. Campbell-Thompson M, Fu A, Kaddis JS et al (2016) Insulitis and beta-cell mass in the natural history of type 1 diabetes. Diabetes 65(3):719–731. https://doi.org/10.2337/db15-0779 - DOI - PubMed
1. Wasserfall C, Nick HS, Campbell-Thompson M et al (2017) Persistence of pancreatic insulin mRNA expression and proinsulin protein in type 1 diabetes pancreata. Cell Metab 26(3):568–575. https://doi.org/10.1016/j.cmet.2017.08.013 - DOI - PubMed - PMC
1. Oram RA, Jones AG, Besser RE et al (2014) The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells. Diabetologia 57(1):187–191. https://doi.org/10.1007/s00125-013-3067-x - DOI - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

MR/P010695/1/MRC_/Medical Research Council/United Kingdom

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

Affiliations

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

Authors

Affiliations

Comment on

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical