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Review
. 2020 Oct;26(4):2017-2022.
doi: 10.1007/s12253-019-00665-6. Epub 2019 Apr 23.

The Role of Interleukin-9 in Cancer

Jacob E Lee  1 , Ziwen Zhu  2 , Qian Bai  2 , Tucker J Brady  1 , Huaping Xiao  1   3 , Mark R Wakefield  2 , Yujiang Fang  4   5
Affiliations
Free article
Review

The Role of Interleukin-9 in Cancer

Jacob E Lee et al. Pathol Oncol Res. 2020 Oct.
Free article

Abstract

Interluekin-9 (IL-9) is produced predominantly by helper T cells such as Th2 and Th9 cells. It normally functions through the activation of a JAK/STAT pathway and plays a critical role in immunity and the pathogenesis of cancer. In cancer, it yields different responses depending on the cancer cell line involved. This review is a summary of what is known about the involvement of IL-9 in various cancer cell lines as well as its role in immunity with a focus on allergic responses.

Keywords: Cancer; Inflammation; Interleukin 9.

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