doi: 10.1007/978-1-4939-9216-4_14.
Flexible Nucleic Acids (FNAs) as Informational Molecules: Enzymatic Polymerization of fNTPs on DNA Templates and Nonenzymatic Oligomerization of RNA on FNA Templates
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- PMID: 31016705
- DOI: 10.1007/978-1-4939-9216-4_14
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Flexible Nucleic Acids (FNAs) as Informational Molecules: Enzymatic Polymerization of fNTPs on DNA Templates and Nonenzymatic Oligomerization of RNA on FNA Templates
Methods Mol Biol.
2019.
Abstract
The methodology enabling enzymatic and nonenzymatic information transfer with FNAs is described. This methodology includes the chemical synthesis of fNTPs and fN phosphoramidites, in addition to protocols for the enzymatic and nonenzymatic transfer of information.
Keywords: DNA; Enzymatic; FNA; Nonenzymatic; Oligomerization; Polymerization; Pre-RNA; Prebiotic; RNA; Synthetic biology; Template-directed.
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