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. 2019:1973:213-236.
doi: 10.1007/978-1-4939-9216-4_14.

Flexible Nucleic Acids (FNAs) as Informational Molecules: Enzymatic Polymerization of fNTPs on DNA Templates and Nonenzymatic Oligomerization of RNA on FNA Templates

Maryline Chemama  1 , Christopher Switzer  2
Affiliations

Flexible Nucleic Acids (FNAs) as Informational Molecules: Enzymatic Polymerization of fNTPs on DNA Templates and Nonenzymatic Oligomerization of RNA on FNA Templates

Maryline Chemama et al. Methods Mol Biol. 2019.

Abstract

The methodology enabling enzymatic and nonenzymatic information transfer with FNAs is described. This methodology includes the chemical synthesis of fNTPs and fN phosphoramidites, in addition to protocols for the enzymatic and nonenzymatic transfer of information.

Keywords: DNA; Enzymatic; FNA; Nonenzymatic; Oligomerization; Polymerization; Pre-RNA; Prebiotic; RNA; Synthetic biology; Template-directed.

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