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Clinical Trial
. 1987 Jan 31;294(6567):272-4.
doi: 10.1136/bmj.294.6567.272.

Impact of gestrinone on the course of asymptomatic endometriosis

E J Thomas, I D Cooke
Clinical Trial

Impact of gestrinone on the course of asymptomatic endometriosis

E J Thomas et al. Br Med J (Clin Res Ed). .

Abstract

A new drug, gestrinone, was subjected to the first double blind, randomised placebo controlled trial of any treatment of endometriosis. The disease deteriorated in eight (47%) of the 17 patients prescribed placebo (95% confidence limits 23% and 71%) compared with none of the 18 patients prescribed gestrinone (p = 0.002). There was a difference in elimination of the endometriosis in the gestrinone group compared with placebo but this was not statistically significant (p = 0.057). There was a significant difference in improvement of the disease in the gestrinone group compared with placebo (p = 0.004), confirming that gestrinone is an effective treatment of endometriosis. Endometriosis deteriorates in at least 23% of patients; as it is impossible to predict in whom this will happen, treatment appears to be warranted in all cases.

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References

    1. Br J Obstet Gynaecol. 1984 Feb;91(2):167-71 - PubMed
    1. Fertil Steril. 1984 Dec;42(6):935-8 - PubMed
    1. Fertil Steril. 1985 Mar;43(3):353-60 - PubMed
    1. Fertil Steril. 1985 Oct;44(4):466-70 - PubMed
    1. Fertil Steril. 1985 Nov;44(5):583-8 - PubMed

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