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. 2019 Apr 24;7(1):57.
doi: 10.1186/s40478-019-0718-2.

Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer's disease

Noura S Al Mulhim  1 , Patrick G Kehoe  1 , J Scott Miners  2
Affiliations

Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer's disease

Noura S Al Mulhim et al. Acta Neuropathol Commun. .
No abstract available

Keywords: Alzheimer’s disease; Angiotensin-II converting enzyme-1 (ACE1); Anti-hypertensives; Renin-angiotensin system.

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Conflict of interest statement

Ethics approval and consent to participate

The use of human brain tissue for this study was approved by the management committee of the South West Dementia Brain Bank (Human Tissue Authority licence number 12273) under the terms of Bristol Research Ethics Committee approval of the brain bank (reference 08/H0106/28 + 5). All participants provided consent to post-mortem removal of whole brain and CSF and the retention of these for use in research. Consent included access to the donor’s medical records to collect information on past medical history relevant to the donation, but that in all publications this information would be anonymised.

Competing interests

JSM, NAM and PGK declare no potential competing of interest with respect to the research, authorship, and/or publication of this article.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Divergent activity of ACE1 domains in Alzheimer’s disease. Bar charts showing (a) significantly higher ACE1 C-domain (Ang-II production) activity in AD compared to age-matched controls and (b) significantly reduced ACE1 N-domain activity (Aβ degradation) compared to age-matched controls in the mid-frontal cortex in AD (n = 72) and age-matched (n = 48). Bars show the median and 95% CI, Mann-Whitney test was used to compare ACE1 C-domain activity between groups. p < 0.05 was considered statistically significant
See this image and copyright information in PMC

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