Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan 7:84:e9-e15.
doi: 10.5114/pjr.2019.81178. eCollection 2019.

Application of the probit method for elastographic evaluation of venous obliterating material after sclerotherapy procedure

Łukasz Paluch  1 , Żaneta Nitek  1 , Katarzyna Sklinda  2 , Bartłomiej Noszczyk  3 , Jerzy Walecki  1
Affiliations

Application of the probit method for elastographic evaluation of venous obliterating material after sclerotherapy procedure

Łukasz Paluch et al. Pol J Radiol. .

Abstract

Purpose: Status after sclerotherapy constitutes a good clinical model for venous thrombosis with known age. The aim of this study was to compare elastographic parameters of material obliterating the great saphenous vein at 7-21 days after polidocanol sclerotherapy.

Material and methods: The study included 60 patients subjected to sclerotherapy due to venous insufficiency (45 women and 15 men, mean age 51.2 ± 14.7 years, range 27-77 years). Elastographic parameters of obliterating material: total area of vessel cross-section (mm2), relative areas (%) covered by tissues with highest, intermediate, and lowest elasticity, were determined 7 ± 1, 14 ± 2, and 21 ± 2 days post-sclerotherapy, respectively. Mean time to partial and complete organisation of the obliterating material was estimated during probit regression analysis.

Results: The relative area of vessel cross-section covered by tissues with the lowest elasticity underwent a statistically significant enlargement, either between the first and the second (Z = 6.725, p < 0.001) or between the second and the third control visit (Z = 6.717, p < 0.001). This corresponded to a change in the structure of the obliterating material from elastic during the first visit (in all patients) to mixed (fibro-elastic) or fibrous during the third visit (71.7% and 28.3% of patients, respectively). Mean time after which the obliterating material reached mixed and fibrous structure on elastographic images was estimated at 14.3 days and > 21 days, respectively.

Conclusions: Ultrasound elastography may accurately reflect the age of venous thrombosis in polidocanol sclerotherapy model. Mixed, fibro-elastic structure of a 14-day-old obliterating material visualised by elastography probably corresponds with chronic thrombus.

Keywords: deep vein thrombosis; imaging; polidocanol; ultrasonography.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interests.

Figures

Figure 1
Figure 1
Obliterating material whose elastographic structure was classified as (A) elastic (age 7 days – predominance of red areas), (B) mixed, fibro-elastic (age 14 days – predominance of green areas), and (C) fibrous (age 21 days – predominance of blue areas)
Figure 2
Figure 2
Time after which obliterating material reached mixed, fibro-elastic structure – results of probit regression analysis
Figure 3
Figure 3
Time to complete organisation of obliterating material – results of probit regression analysis
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Heit JA. The epidemiology of venous thromboembolism in the community. Arterioscler Thromb Vasc Biol. 2008;28:370–372. - PMC - PubMed
    1. Stein PD, Hull RD, Kayali F, et al. Venous thromboembolism according to age: the impact of an aging population. Arch Intern Med. 2004;164:2260–2265. - PubMed
    1. Silverstein MD, Heit JA, Mohr DN, et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998;158:585–593. - PubMed
    1. Faller N, Limacher A, Mean M, et al. Predictors and causes of long-term mortality in elderly patients with acute venous thromboembolism: a prospective cohort study. Am J Med. 2017;130:198–206. - PubMed
    1. Xing KH, Morrison G, Lim W, et al. Has the incidence of deep vein thrombosis in patients undergoing total hip/knee arthroplasty changed over time? A systematic review of randomized controlled trials. Thromb Res. 2008;123:24–34. - PubMed