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Editorial
. 2019 Mar;11(3):632-635.
doi: 10.21037/jtd.2019.02.37.

Dietary myo-inositol chemoprevents lung carcinogenesis via boosting immune system in Kras mouse model

Affiliations
Editorial

Dietary myo-inositol chemoprevents lung carcinogenesis via boosting immune system in Kras mouse model

Raziye Piranlioglu et al. J Thorac Dis. 2019 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Myo-inositol, a sugar alcohol, shows a strong chemopreventive activity in KRAS driven-lung cancer model of CC-LR mice by reducing circulating IL-6 levels and by switching to anti-tumoral M1 macrophages. IL-6, interleukin 6.

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References

    1. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539-45. 10.1016/S0140-6736(00)04046-0 - DOI - PubMed
    1. Korkaya H, Kim GI, Davis A, et al. Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. Mol Cell 2012;47:570-84. 10.1016/j.molcel.2012.06.014 - DOI - PMC - PubMed
    1. Korkaya H, Liu S, Wicha MS. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest 2011;121:3804-9. 10.1172/JCI57099 - DOI - PMC - PubMed
    1. Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res 2008;14:6735-41. 10.1158/1078-0432.CCR-07-4843 - DOI - PubMed
    1. Scheller J, Rose-John S. Interleukin-6 and its receptor: from bench to bedside. Med Microbiol Immunol 2006;195:173-83. 10.1007/s00430-006-0019-9 - DOI - PubMed