Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb;130(2):275-282.
doi: 10.1002/lary.27995. Epub 2019 Apr 25.

Treatment modalities in sinonasal mucosal melanoma: A national cancer database analysis

Ashwin Ganti  1 , Anish Raman  1 , Aryan Shay  1 , Hannah N Kuhar  1 , Samuel R Auger  1 , Tirth Patel  2 , Edward C Kuan  3 , Aidnag Z Diaz  4 , Pete S Batra  2 , Bobby A Tajudeen  2
Affiliations

Treatment modalities in sinonasal mucosal melanoma: A national cancer database analysis

Ashwin Ganti et al. Laryngoscope. 2020 Feb.

Abstract

Objectives/hypothesis: The purpose of this study was to investigate the association of demographic factors, tumor stage, and treatment modalities for overall survival in patients with sinonasal mucosal melanoma (SNMM).

Study design: Retrospective database review.

Methods: The National Cancer Database was queried for patients of all ages with SNMM between 2004 and 2015. Univariate Kaplan-Meier and multivariate Cox regression analyses were performed to evaluate the association of suspected prognostic factors with overall survival.

Results: A total of 1,874 patients with SNMM were included in the analysis. The 5-year overall survival was 24%. Prognostic factors associated with decreased survival include advanced age (hazard ratio [HR]: 1.02, 95% confidence interval [CI]: 1.01-1.03), T4 disease (HR: 1.44, 95% CI: 1.09-1.89), and presence of distant metastases (HR: 3.22. 95% CI: 2.06-5.04). Improved survival was associated with surgical resection only when margins were negative (HR: 0.44; 95% CI: 0.30-0.65). In patients with metastatic disease, administration of immunotherapy (HR: 0.14; 95% CI: 0.04-0.49) was associated with improved survival. Surgical approach, radiotherapy, and chemotherapy were nonsignificant predictors of survival.

Conclusions: This investigation is the largest to date to analyze the association of treatment modalities with overall survival in SNMM. Surgery remains the mainstay of treatment in patients with SNMM. However, administration of immunotherapy may confer survival benefit to patients with metastatic disease.

Level of evidence: NA Laryngoscope, 130:275-282, 2020.

Keywords: Mucosal melanoma; National Cancer Database; malignancy; overall survival; sinonasal.

PubMed Disclaimer

References

BIBLIOGRAPHY

    1. Gal TJ, Silver N, Huang B. Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope 2011;121:2026-2033.
    1. Gilain L, Houette A, Montalban A, Mom T, Saroul N. Mucosal melanoma of the nasal cavity and paranasal sinuses. Eur Ann Otorhinolaryngol Head Neck Dis 2014;131:365-369.
    1. Ascierto PA, Accorona R, Botti G, et al. Mucosal melanoma of the head and neck. Crit Rev Oncol Hematol 2017;112:136-152.
    1. Patel SG, Prasad ML, Escrig M, et al. Primary mucosal malignant melanoma of the head and neck. Head Neck 2002;24:247-257.
    1. Konuthula N, Khan MN, Parasher A, et al. The presentation and outcomes of mucosal melanoma in 695 patients. Int Forum Allergy Rhinol 2017;7:99-105.

LinkOut - more resources