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Review
. 2019 Aug;44(8):716-728.
doi: 10.1016/j.tibs.2019.03.005. Epub 2019 Apr 22.

Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation

Konstantin K Turoverov  1 , Irina M Kuznetsova  2 , Alexander V Fonin  2 , April L Darling  3 , Boris Y Zaslavsky  4 , Vladimir N Uversky  5
Affiliations
Review

Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation

Konstantin K Turoverov et al. Trends Biochem Sci. 2019 Aug.

Abstract

At the turn of this century, cardinal changes took place in the perceptions of the structure and function of proteins, as well as in the organizational principles of membrane-less organelles. As a result, the model of the organization of living matter is changing to one described by highly dynamic biological soft matter positioned at the edge of chaos. Intrinsically disordered proteins (IDPs) and membrane-less organelles are key examples of this new outlook and may represent a critical foundation of life, defining its complexity and the evolution of living things.

Keywords: biological soft matter; edge of chaos; emergent behavior; liquid-liquid phase transition.

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