Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Feb 1;165(2):531-45.
doi: 10.1084/jem.165.2.531.

Molecular dissection of the murine antibody response to streptococcal group A carbohydrate

C T Lutz, T L Bartholow, N S Greenspan, R J Fulton, W J Monafo, R M Perlmutter, H V Huang, J M Davie

Molecular dissection of the murine antibody response to streptococcal group A carbohydrate

C T Lutz et al. J Exp Med. .

Abstract

Monoclonal antibodies (mAb) to streptococcal group A carbohydrate (GAC) are encoded by a minimum of two VH, four JH, four V kappa, three J kappa, one V lambda, and one J lambda gene segments. The IdX, IdI-1, and Id5 idiotypic determinants are expressed by anti-GAC mAb and are found on free kappa chains. Each pattern of these determinants is encoded by a distinct V kappa gene segment, apparently without the requirement for a particular J kappa, VH, or JH gene segment, or somatic mutation. In contrast, the binding site-associated idiotypic determinant IdI-3a does not correlate with any single V or J gene segment.

PubMed Disclaimer

References

    1. Nature. 1983 Apr 14;302(5909):575-81 - PubMed
    1. Adv Immunol. 1984;35:1-37 - PubMed
    1. Biochem J. 1983 Apr 1;211(1):173-80 - PubMed
    1. Eur J Immunol. 1984 Oct;14(10):922-30 - PubMed
    1. Nature. 1984 Oct 25-31;311(5988):727-33 - PubMed

Publication types

MeSH terms