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Meta-Analysis
. 2019 Apr;98(17):e15338.
doi: 10.1097/MD.0000000000015338.

Prognostic value of tumor necrosis in gastrointestinal stromal tumor: A meta-analysis

Mengshi Yi  1 , Lin Xia  1 , Yan Zhou  2 , Xiaoting Wu  1 , Wen Zhuang  1 , Yi Chen  1 , Rui Zhao  1 , Qianyi Wan  1 , Liang Du  3 , Yong Zhou  1
Affiliations
Meta-Analysis

Prognostic value of tumor necrosis in gastrointestinal stromal tumor: A meta-analysis

Mengshi Yi et al. Medicine (Baltimore). 2019 Apr.

Abstract

Background and aims: There is currently no consensus regarding the influence of tumor necrosis on the prognosis of gastrointestinal stromal tumors (GISTs). Therefore, we conducted a meta-analysis to determine the prognostic role of tumor necrosis in patients with GIST.

Methods: PubMed, Embase, and Web of Science electronic databases were searched from their inception to March 2018. Studies reporting data on the relationship between tumor necrosis and GIST prognosis were eligible. The measure of the effect of interest was the odds ratios (ORs) with 95% confidence intervals (CIs). This study has been registered in the Prospero (number CRD42018096036).

Results: In total, 18 studies including 2320 patients were identified. The total odds of tumor necrosis were associated with a poor GIST prognosis (OR = 5.54, 95% CI = 4.39-6.99). Subgroup analysis of different observed outcomes indicated that tumor necrosis was associated with a decreased disease-free survival (OR = 7.08, 95% CI = 4.78-10.49), recurrence-free survival (OR = 3.96, 95% CI = 2.48-6.32), and overall survival (OR = 4.29, 95% CI = 2.02-9.13). In addition, any tumor site, tumor size, follow-up time, ethnicity, different outcomes of GIST, and different degrees of positive staining of immunohistochemical markers subgroups showed a significantly increased risk of a poor prognosis.

Conclusions: Tumor necrosis may likely predict a poorer prognosis for GIST. However, further well-designed prospective studies with large sample size are required in the future.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow chart of study selection.
Figure 2
Figure 2
Pooled ORs on the association of tumor necrosis with GIST prognosis. GIST = gastrointestinal stromal tumor, OR = odds ratio.
Figure 3
Figure 3
Funnel pots by Egger's test.
See this image and copyright information in PMC

References

    1. Joensuu H, Hohenberger P, Corless CL. Gastrointestinal stromal tumour. Lancet 2013;382:973–83. - PubMed
    1. Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006;130:1466–78. - PubMed
    1. Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998;279:577–80. - PubMed
    1. Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003;299:708–10. - PubMed
    1. Joensuu H, Vehtari A, Riihimaki J, et al. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol 2012;13:265–74. - PubMed

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