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. 2019 Apr;98(17):e15370.
doi: 10.1097/MD.0000000000015370.

Increased risk of migraine in patients with psoriasis: A longitudinal follow up study using a national sample cohort

Chanyang Min  1   2   3 , Hyoseob Lim  4 , Jae-Sung Lim  5 , Songyong Sim  6 , Hyo Geun Choi  1   2
Affiliations

Increased risk of migraine in patients with psoriasis: A longitudinal follow up study using a national sample cohort

Chanyang Min et al. Medicine (Baltimore). 2019 Apr.

Abstract

Both psoriasis and migraine are associated with inflammatory diseases. However, few studies have been conducted the increased risk of migraine in psoriasis patients. The aim of this study was to identify whether the psoriasis increases the risk of migraine. This study used the national cohort study data collected by the Korean Health Insurance Review and Assessment from 2002 to 2013. Patients with psoriasis (n = 11,071) and control participants (n = 44,284) were selected and matched 1:4 by age, sex, income, region of residence, and past medical history of hypertension, diabetes, and dyslipidemia. This study used Cox-proportional hazard model for calculating hazard ratio (HR) with crude and adjusted model. Stratification by age and sex was analyzed. Migraines occurred significantly more frequently in psoriasis patients than in control participants (adjusted HR = 1.16, 95% confidence interval (CI) = 1.04-1.31, P <.05). In the stratification analysis, migraines occurred significantly more frequently in psoriasis patients than in control participants only in the group of middle-aged males (adjusted HR = 1.62 95% CI = 1.22-2.13, P = .001). In conclusion, psoriasis might increase the risk of migraine.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
A schematic illustration of the participant selection process that was used in the present study. Out of a total of 1,125,691 participants, 11,071 psoriasis patients were matched with 44,284 control participants by age, sex, income group, region of residence, and past medical history.
See this image and copyright information in PMC

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