Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul;33(3):115-129.
doi: 10.1016/j.trre.2019.03.002. Epub 2019 Apr 5.

Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation

Zachary Fitch  1 , Robin Schmitz  2 , Jean Kwun  2 , Bernhard Hering  3 , Joren Madsen  2 , Stuart J Knechtle  4
Affiliations
Review

Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation

Zachary Fitch et al. Transplant Rev (Orlando). 2019 Jul.

Abstract

Research in transplant immunology using non-human primate (NHP) species to evaluate immunologic strategies to prevent rejection and prolong allograft survival has yielded results that have translated successfully into human organ transplant patient management. Other therapies have not proceeded to human translation due to failure in NHP testing, arguably sparing humans the futility and risk of such testing. The NHP transplant models are ethically necessary for drug development in this field and provide the closest analogue to human transplant patients available. The refinement of this resource with respect to colony MHC typing, reagent and assay development, and availability to the research community has greatly enhanced knowledge about transplant immunology and drug development.

PubMed Disclaimer

References

    1. Kirk AD. Transplantation tolerance: a look at the nonhuman primate literature in the light of modern tolerance theories. Crit Rev Immunol. 1999;19(5–6):349–388. http://www.ncbi.nlm.nih.gov/pubmed/10647743. Accessed August 23, 2018. - PubMed
    1. Kirk AD. Crossing the bridge: large animal models in translational transplantation research. Immunol Rev. 2003;196:176–196. http://www.ncbi.nlm.nih.gov/pubmed/14617205. Accessed August 23, 2018. - PubMed
    1. Rose SM, Blustein N, Rotrosen D. Recommendations of the expert panel on ethical issues in clinical trials of transplant tolerance. National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Transplantation. 1998;66(9):1123–1125. http://www.ncbi.nlm.nih.gov/pubmed/9825804. Accessed August 20, 2018. - PubMed
    1. Anderson DJ, Kirk AD. Primate models in organ transplantation. Cold Spring Harb Perspect Med. 2013;3(9):a015503. doi:10.1101/cshperspect.a015503 - DOI - PMC - PubMed
    1. Kitchens WH, Adams AB. Nonhuman primate models of transplant tolerance. Curr Opin Organ Transplant. 2016;21(1):59–65. doi:10.1097/MOT.0000000000000271 - DOI - PubMed

Publication types