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. 1978 Aug;16(7-8):641-9.
doi: 10.1007/BF00484720.

Origin of the multiple components of human alpha1-antitrypsin

A Yoshida, M Wessels

Origin of the multiple components of human alpha1-antitrypsin

A Yoshida et al. Biochem Genet. 1978 Aug.

Abstract

Multiple components of human alpha1-antitrypsin were separated by preparative starch gel electrophoresis, and the sialic acid contents of these components were determined. The acidic components contained more sialic acid per molecule than the basic components. The molecular sizes of these components were identical, excluding the possibility of polymerization of the inhibitor in the formation of the multiple components. Consequently, the multiple components of the inhibitor are primarily due to differences in the sialic acid content of each component. Three major components contain eight, seven, and six sialic acid residues per molecule, respectively.

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References

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