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. 1978 Oct 15;176(1):339-42.
doi: 10.1042/bj1760339.

A possible role for 5-hydroxytryptamine as a mediator for calcitonin actions on the gastrointestinal tract and pancreas in rats

A M Nakhla, A Latif

A possible role for 5-hydroxytryptamine as a mediator for calcitonin actions on the gastrointestinal tract and pancreas in rats

A M Nakhla et al. Biochem J. .

Abstract

Administration of pig calcitonin (10 M.R.C. units/kg body wt.) produced an immediate decrease in 5-hydroxytryptamine content in the antrum-duodenum region and ileum. In contrast, the hormone treatment rapidly increased the concentration of 5-hydroxytryptamine in the blood and pancreas. Serum immunoreactive gastrin did not change over a period of 3h after calcitonin administration. The results suggest that the release of 5-hydroxytryptamine probably mediates calcitonin actions on the gastrointestinal tract and pancreas.

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