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. 1978 Nov;38(5):606-11.
doi: 10.1038/bjc.1978.256.

E-rosette-forming cells at 29 degrees C: an assay for the evaluation of the immune status of cancer patients

P C Quan, P Burtin
Free PMC article

E-rosette-forming cells at 29 degrees C: an assay for the evaluation of the immune status of cancer patients

P C Quan et al. Br J Cancer. 1978 Nov.
Free PMC article

Abstract

High-affinity rosette-forming T-cell assays were performed by incubation of peripheral-blood mononuclear cells with sheep erythrocytes (E) at 29 degrees C. As compared with normal controls, the levels of high-affinity rosette-forming cells (RFC) were much more frequently depressed in cancer patients than were the total E-RFC incubated at 4 degrees C. Only 2/83 normal controls had less than 38% 29 degrees C E-RFC (mean 48 +/- 5), whilst 78/89 cancer patients were below this level. The few postoperative patients tested exhibited a normal range of 29 degrees C E-RFC. The 29 degrees C E-rosette assay gives reproducible counts of a T-cell subset, and is a sensitive assay for evaluating the immune status of cancer patients.

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