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Case Reports
. 2019 May-Jun;36(3):236-238.
doi: 10.4103/lungindia.lungindia_111_16.

Atypical carcinoid tumor of the lung: A rare entity

Rajiv Garg  1 , Rahul Kumar  1 , Pradyumn Singh  2 , Silpa Kshetrimayum  1
Affiliations
Case Reports

Atypical carcinoid tumor of the lung: A rare entity

Rajiv Garg et al. Lung India. 2019 May-Jun.

Abstract

Carcinoids account for approximately 2% of all lung tumors, and the atypical carcinoids (ACs) are much rarer than typical carcinoid. Here, we report a rare case of AC tumor of the lung. A 50-year-old female patient presented with left-sided chest pain for 1 year, cough for 6 months, and loss of appetite for 6 months. Contrast-enhanced computed tomography scan of the thorax revealed an ill-defined heterogeneously enhancing soft-tissue attenuation lesion in the mediastinum following which transthoracic biopsy was done. Histomorphology and immunohistochemistry were consistent with AC, a neuroendocrine tumor. Combination chemotherapy consisting of cisplatin and etoposide was administered as initial chemotherapy.

Keywords: Atypical carcinoid; intrathoracic mass; neuroendocrine tumor.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Contrast-enhanced computed tomography scan of the thorax showing that the lesion is encasing branches of the arch of the aorta completely and the arch of the aorta partially
Figure 2
Figure 2
Histopathology of atypical carcinoid showing tissue infiltration by a tumor disposed in nests and trabeculae. The tumor cells are polygonal with moderately pleomorphic nuclei, granular chromatin, and moderate amount of eosinophilic cytoplasm. Mitotic figures (3/10 high-power fields) and apoptotic bodies are evident
Figure 3
Figure 3
Immunochemistry of atypical carcinoid positive for chromogranin
See this image and copyright information in PMC

References

    1. Vuitch F, Sekido Y, Fong K, Mackay B, Minna JD, Gazdar AF, et al. Neuroendocrine tumors of the lung. Pathology and molecular biology. Chest Surg Clin N Am. 1997;7:21–47. - PubMed
    1. World Health Organization. Classification of Tumors Pathology and Genetics Tumors of the Lung, Pleura and Heart. Lyon, France: IARC Press; 2004.
    1. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, et al. One hundred years after “carcinoid”: Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26:3063–72. - PubMed
    1. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97:934–59. - PubMed
    1. Fink G, Krelbaum T, Yellin A, Bendayan D, Saute M, Glazer M, et al. Pulmonary carcinoid: Presentation, diagnosis, and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest. 2001;119:1647–51. - PubMed

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