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. 2019 Jan-Mar;13(1):97-104.
doi: 10.4103/aer.AER_12_19.

Oral Pregabalin as Premedication on Anxiolysis and Stress Response to Laryngoscopy and Endotracheal Intubation in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Double-Blind Study

Dheer Singh  1 , Jaybrijesh Singh Yadav  1 , Birendra Kumar Jamuda  1 , Pooja Singh  2
Affiliations

Oral Pregabalin as Premedication on Anxiolysis and Stress Response to Laryngoscopy and Endotracheal Intubation in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Double-Blind Study

Dheer Singh et al. Anesth Essays Res. 2019 Jan-Mar.

Abstract

Background: Direct laryngoscopy and tracheal intubation lead to increase in heart rate and blood pressure. This can cause serious complications in patients with coronary artery disease, reactive airways, or intracranial neuropathology. Preoperative anxiety is associated with greater level of postoperative pain. Attenuation of anxiety and hemodynamic response to laryngoscopy and intubation are cornerstone of better anesthetic outcome. Gabapentinoids (gabapentin and pregabalin) have been known to possess anxiolytic, analgesic, and anticonvulsant properties.

Aim: The aim of this study is to determine the effects of oral pregabalin on anxiolysis and attenuation of stress response to laryngoscopy and endotracheal intubation.

Study design: This was a prospective randomized double-blind placebo controlled study.

Materials and methods: A total of 60 patients ASA physical status Class I and II, undergoing elective laparoscopic cholecystectomy, were randomly allocated into two groups receiving either oral placebo or oral pregabalin 150 mg, 60 min before induction of anesthesia. Visual analog scale (VAS) for anxiety was recorded before, and 60 min after giving the drug. Hemodynamic parameters (heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure) were recorded before, and 60 min after giving drug, during and 2, 4, 6, 8, and 10 min after intubation.

Results: During preinduction, pregabalin showed a decrease in VAS and attenuation of stress response to laryngoscopy and intubation compared to that of placebo. The premedicated patients were hemodynamically stable perioperatively without side effects.

Conclusion: Pregabalin is effective in attenuating preoperative anxiety and stress response to endotracheal intubation.

Keywords: Anxiolysis; endotracheal intubation; pregabalin; stress response.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Chart 1
Chart 1
Consort Flow Diagram. Group A=Placebo; Group B=Pregabalin
Figure 1
Figure 1
Line diagram showing comparison of change in heart rate across time periods among the study groups
Figure 2
Figure 2
Line diagram showing comparison of change in systolic blood pressure across time periods among the study groups
Figure 3
Figure 3
Line diagram showing comparison of change in diastolic blood pressure across time periods among the groups
Figure 4
Figure 4
Line diagram showing comparison of changes in mean arterial pressure across time periods among the study groups
See this image and copyright information in PMC

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