Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Feb 23;10(6):1417-1433.
doi: 10.7150/jca.28406. eCollection 2019.

Genetic Polymorphisms of DNA Repair Pathways in Sporadic Colorectal Carcinogenesis

Jingwei Liu  1 , Bowen Zheng  1 , Ying Li  1 , Yuan Yuan  1 , Chengzhong Xing  1
Affiliations
Review

Genetic Polymorphisms of DNA Repair Pathways in Sporadic Colorectal Carcinogenesis

Jingwei Liu et al. J Cancer. .

Abstract

DNA repair systems play a critical role in maintaining the integrity and stability of the genome, which mainly include base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR) and double-strand break repair (DSBR). The polymorphisms in different DNA repair genes that are mainly represented by single-nucleotide polymorphisms (SNPs) can potentially modulate the individual DNA repair capacity and therefore exert an impact on individual genetic susceptibility to cancer. Sporadic colorectal cancer arises from the colorectum without known contribution from germline causes or significant family history of cancer or inflammatory bowel disease. In recent years, emerging studies have investigated the association between polymorphisms of DNA repair system genes and sporadic CRC. Here, we review recent insights into the polymorphisms of DNA repair pathway genes, not only individual gene polymorphism but also gene-gene and gene-environment interactions, in sporadic colorectal carcinogenesis.

Keywords: DNA repair; carcinogenesis; colorectal cancer; polymorphism.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
BER pathway gene polymorphisms and sporadic CRC susceptibility.
Figure 2
Figure 2
NER pathway gene polymorphisms and sporadic CRC susceptibility.
Figure 3
Figure 3
MMR pathway gene polymorphisms and sporadic CRC susceptibility.
Figure 4
Figure 4
DSBR pathway gene polymorphisms and sporadic CRC susceptibility.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Roos WP, Thomas AD, Kaina B. DNA damage and the balance between survival and death in cancer biology. Nature reviews Cancer. 2016;16(1):20–33. - PubMed
    1. Decordier I, Loock KV, Kirsch-Volders M. Phenotyping for DNA repair capacity. Mutat Res. 2010;705(2):107–129. - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA: a cancer journal for clinicians. 2015;65(1):5–29. - PubMed
    1. Schreuders EH, Ruco A, Rabeneck L, Schoen RE, Sung JJ, Young GP, Kuipers EJ. Colorectal cancer screening: a global overview of existing programmes. Gut. 2015;64(10):1637–1649. - PubMed
    1. Wallace SS. Base excision repair: a critical player in many games. DNA Repair (Amst) 2014;19:14–26. - PMC - PubMed