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Case Reports
. 2019 Mar 28:2019:6098747.
doi: 10.1155/2019/6098747. eCollection 2019.

Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case

Helen J Trihia  1 , Natasa Novkovic  1 , Ioannis Provatas  1 , Anastasios Mavrogiorgis  2 , Evangelos Lianos  3
Affiliations
Case Reports

Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case

Helen J Trihia et al. Case Rep Pathol. .

Abstract

Sarcomas of the breast constitute less than 1% of all malignant breast tumors and primary rhabdomyosarcoma (RMS) is a very rare entity with limited case reports in the literature. RMS is common in children and adolescents and rare in adults. Primary RMS arising from the breast is exceedingly rare in adults. We report a case of a primary RMS of the breast in a 60-year-old woman, who presented in an early stage, mimicking invasive ductal carcinoma clinically and is in complete remission after three years of diagnosis and one year of treatment.

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Figures

Figure 1
Figure 1
Mammography demonstrates a stable oval, circumscribed mass in the medial part of the left breast.
Figure 2
Figure 2
Macroscopic appearance of a well circumscribed, solid with subtle nodularity tumor, with central areas of necrosis.
Figure 3
Figure 3
Histological appearance of infiltrative lesion (on the right) of the breast (on the left) composed of sheets of small round blue cells (Hematoxylin & eosin, original magnification X50).
Figure 4
Figure 4
Histological examination shows solid infiltration of small/intermediate neoplastic cells displaying round hyperchromatic pleomorphic nuclei with indistinct cytoplasm and brisk mitotic activity (Hematoxylin & eosin, original magnification X200).
Figure 5
Figure 5
Same as Figure 4, higher magnification.
Figure 6
Figure 6
Tumor cells grow in nests separated by hyalinized fibrous septa (X200, H&E stain).
Figure 7
Figure 7
Tumor cells with extensive necrosis (H&E, X200).
Figure 8
Figure 8
Alveolar pattern with necrosis (H&E, X200).
Figure 9
Figure 9
Immunohistochemistry shows positive cytoplasmic (dot-like) staining of the tumor cells for desmin (X200).
Figure 10
Figure 10
Immunohistochemistry shows positive nuclear staining of the tumor cells for myogenin (X100).
Figure 11
Figure 11
Immunohistochemistry shows positive nuclear staining of the tumor cells for myo-D1 (X200).
Figure 12
Figure 12
Immunohistochemistry shows positive cytoplasmic (dot-like) staining of the tumor cells for neurofilament (NF) (X100).
Figure 13
Figure 13
Immunohistochemistry shows positive cytoplasmic staining of the tumor cells for bcl-2 (X400).
See this image and copyright information in PMC

References

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