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Editorial
. 2019 Mar;7(Suppl 1):S2.
doi: 10.21037/atm.2019.01.06.

Meningeal lymphatics in aging and Alzheimer's disease

Russell J Jaffe  1 , Rajnish S Dave  1 , Siddappa N Byrareddy  1
Affiliations
Editorial

Meningeal lymphatics in aging and Alzheimer's disease

Russell J Jaffe et al. Ann Transl Med. 2019 Mar.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Paravascular efflux of Aβ via the meningeal lymphatic vessels. The flow of Aβ from the brain to the dCLNs is illustrated. (A) The efflux of Aβ (and other macromolecular wastes from the CNS) occurs uninterrupted via the meningeal lymphatic vessels; (B) efflux of Aβ is hampered in an aging brain and can be experimentally mimicked by ablation with photoconverted Visudyne; (C) alternatively, intersection with VEGF expands the lymphatic vessels. This expansion of the meningeal lymphatic vessels increases efflux of Aβ. Aβ, amyloid β; dCLNs, deep cervical lymph nodes; CNS, central nervous system; VEGF, vascular endothelial growth factor.
See this image and copyright information in PMC

Comment on

  • Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease.
    Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J. Da Mesquita S, et al. Nature. 2018 Aug;560(7717):185-191. doi: 10.1038/s41586-018-0368-8. Epub 2018 Jul 25. Nature. 2018. PMID: 30046111 Free PMC article.

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