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Editorial
. 2019 Mar;7(Suppl 1):S30.
doi: 10.21037/atm.2019.01.80.

Mind the gap: renal tubule responses to injury and the role of Cxcl12 and Myc

Veronika Sander  1 , Richard W Naylor  2 , Alan J Davidson  1
Affiliations
Editorial

Mind the gap: renal tubule responses to injury and the role of Cxcl12 and Myc

Veronika Sander et al. Ann Transl Med. 2019 Mar.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Schematics of the proposed signaling events involved in the early response of renal tubules to injury in zebrafish (left-hand panel) and mouse (right-hand panel) based on the study of Yakulov and colleagues. Repair of the pronephric tubule following laser-mediated ablation in a 2-day old zebrafish occurs by rapid cell migration that is regulated by Cxcl12a-Cxcr4b signaling and Myca. The same factors are involved in the tubular response to ischemia/reperfusion injury in the mouse and appear to act upstream of retinoic acid (RA) signaling, a known inducer of anti-inflammatory (M2 spectrum) macrophages. A stimulation of glycolysis by Cxcl12a and Myc is suggested to underlie the tubular response to injury in both models, where the ATP generated may drive migration in zebrafish and help offset the energy depletion caused by the hypoxia in the mouse.
See this image and copyright information in PMC

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